Genetic variants of retinol-binding protein 4 in adolescents are associated with liver function and inflammatory markers but not with obesity and insulin resistance
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Obesity is a global health problem not only in adults but also in adolescents. It increases the risk of metabolic disorders such as type 2 diabetes (T2D), hypertension, insulin resistance (IR) and dyslipidemia. The adipose tissues which store energy is also an endocrine organ which influences insulin sensitivity by releasing multiple cytokines, including retinol-binding protein 4 (RBP4) (Rosen and Spiegelman 2006). RBP4 is a novel adipokine that has been suggested to be related to IR, dyslipidemia and proinflammatory status.
The expression of RBP4 has been reported to be elevated in the adipose tissue of adipose-Glut4 knockout mice, and injections of recombinant RBP4 in normal mice have shown to cause IR. In addition, an increase in serum RBP4 has been reported to diminish the expression of glucose transporter 4 in adipocytes, induce the hepatic expression of the gluconeogenic enzyme and impair insulin signalling in muscles (Yang et al. 2005).
The RBP4gene maps on...
Keywordsretinol-binding protein 4 insulin resistance obesity adolescence single-nucleotide polymorphism.
The study was supported by grant from the Cardinal Tien Hospital (CTH-103-1-2C01) and Tri-Service General Hospital (TSGH-C103-129).
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