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Journal of Genetics

, Volume 93, Issue 3, pp 667–682 | Cite as

F1 hybrids of BALB/c and C57BL/6 mouse strains respond differently to low-dose ionizing radiation exposure

  • SANJAY MUKHERJEE
  • K. B. SAINIS
  • DEEPTI D. DEOBAGKAREmail author
RESEARCH ARTICLE

Abstract

There are evidences to show that response to ionizing radiations have genetic influence. To investigate this further, reciprocal F1 hybrids were genereted by crossbreeding the radiation-susceptible BALB/c mouse strain with resistant C57BL/6 in a sex-specific manner (BALB/c ♂× C57BL/6 ♀ = B6BcF1; C57BL/6 ♂ × BALB/c ♀ = BcB6F1). These hybrids were compared with each other and to the parental strains with respect to transcriptional responses to low-dose ionizing radiation exposure (LDIR). The two F1 hybrids showed drastic differences in their gene expression profiles to ionizing radiation exposure particularly in case of the genes involved in DNA damage response and repair process. Also, the inheritance pattern of the gene expression was found to be complex and could not be explained solely on the basis of parental expression pattern. It was concluded that there is a differential transmission of susceptible trait alleles from the parents to F1 progeny which is dependent on the sex of the parent mouse strain used to set up the crosses and other environmental factors.

Keywords

low-dose ionizing radiation F1 hybrids DNA repair gene expression microarray inheritance. 

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Copyright information

© Indian Academy of Sciences 2014

Authors and Affiliations

  • SANJAY MUKHERJEE
    • 1
  • K. B. SAINIS
    • 2
  • DEEPTI D. DEOBAGKAR
    • 1
    Email author
  1. 1.Department of ZoologyUniversity of PunePuneIndia
  2. 2.Bhabha Atomic Research CentreMumbaiIndia

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