Journal of Genetics

, Volume 92, Issue 1, pp 109–113

A study of the frequency of methylation of gene promoter regions in colorectal cancer in the Taiwanese population

Research Note


colorectal cancer DNA methylation Taiwanese population 


  1. Azuara D., Rodriguez-Moranta F., de Oca J., Soriano-Izquierdo A., Mora J., Guardiola J. et al. 2010 Novel methylation panel for the early detection of colorectal tumors in stool DNA. Clin. Colorectal Cancer 9, 168–176.PubMedCrossRefGoogle Scholar
  2. Brenner H., Altenhofen L. and Hoffmeister M. 2010 Sex, age, and birth cohort effects in colorectal neoplasms: a cohort analysis. Ann. Int. Med. 152, 697–703.PubMedCrossRefGoogle Scholar
  3. Chen S. P., Chiu S. C., Wu C. C., Lin S. Z., Kang J. C., Chen Y. L. et al. 2009 The association of methylation in the promoter of APC and MGMT and the prognosis of Taiwanese CRC patients. Genet. Test Mol. Biomarkers 13, 67–71.PubMedCrossRefGoogle Scholar
  4. Davies R. J., Miller R. and Coleman N. 2005 Colorectal cancer screening: prospects for molecular stool analysis. Nat. Rev. Cancer 5, 199–209.PubMedGoogle Scholar
  5. Esteller M. 2007 Cancer epigenomics: DNA methylomes and histone-modification maps. Nat. Rev. Genet. 8, 286–298.PubMedCrossRefGoogle Scholar
  6. Esteller M. 2011 Epigenetic changes in cancer. F1000 Biol. Rep. 3, 9.PubMedCrossRefGoogle Scholar
  7. Feng Q., Hawes S. E., Stern J. E., Wiens L., Lu H., Dong Z. M. et al. 2008 DNA methylation in tumor and matched normal tissues from non-small cell lung cancer patients. Cancer Epidemiol. Biomarkers Prev. 17, 645–654.PubMedCrossRefGoogle Scholar
  8. Hinoue T., Weisenberger D. J., Lange C. P., Shen H., Byun H. M., Van Den Berg D. et al. 2012 Genome-scale analysis of aberrant DNA methylation in colorectal cancer. Genome Res. 22, 271–282.PubMedCrossRefGoogle Scholar
  9. Hitchins M. P., Rapkins R. W., Kwok C. T., Srivastava S., Wong J. J., Khachigian L. M. et al. 2011 Dominantly inherited constitutional epigenetic silencing of MLH1 in a cancer-affected family is linked to a single nucleotide variant within the 5′ΥTP. Cancer Cell 20, 200–213.PubMedCrossRefGoogle Scholar
  10. Huang C. C., Chien W. P., Wong R. H., Cheng Y. W., Chen M. C. and Lee H. 2009 NAT2 fast acetylator genotype and MGMT promoter methylation may contribute to gender difference in K-RAS mutation occurrence in Taiwanese colorectal cancer. Environ. Mol. Mutagen. 50, 127–133.PubMedCrossRefGoogle Scholar
  11. Iacopetta B., Grieu F. and Amanuel B. 2010 Microsatellite instability in colorectal cancer. Asia Pac. J. Clin. Oncol. 6, 260–269.PubMedCrossRefGoogle Scholar
  12. Jemal A., Bray F., Center M. M., Ferlay J., Ward E. and Forman D. 2011 Global cancer statistics. CA Cancer J. Clin. 61, 69–90.PubMedCrossRefGoogle Scholar
  13. Kangaspeska S., Stride B., Metivier R., Polycarpou-Schwarz M., Ibberson D., Carmouche R. P. et al. 2008 Transient cyclical methylation of promoter DNA. Nature 452, 112–115.PubMedCrossRefGoogle Scholar
  14. Kim M. S., Lee J. and Sidransky D. 2010 DNA methylation markers in colorectal cancer. Cancer Metastasis Rev. 29, 181–206.PubMedCrossRefGoogle Scholar
  15. Kneip C., Schmidt B., Seegebarth A., Weickmann S., Fleischhacker M., Liebenberg V. et al. 2011 SHOX2 DNA methylation is a biomarker for the diagnosis of lung cancer in plasma. J. Thorac. Oncol. 6, 1632–1638.PubMedCrossRefGoogle Scholar
  16. Levin B., Lieberman D. A., McFarland B., Andrews K. S., Brooks D., Bond J. et al. 2008 Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology. Gastroenterology 134, 1570–1595.PubMedCrossRefGoogle Scholar
  17. Metivier R., Gallais R., Tiffoche C., Le Peron C., Jurkowska R. Z., Carmouche R. P. et al. 2008 Cyclical DNA methylation of a transcriptionally active promoter. Nature 452, 45–50.PubMedCrossRefGoogle Scholar
  18. Mitomi H., Fukui N., Tanaka N., Kanazawa H., Saito T., Matsuoka T. et al. 2010 Aberrant p16((INK4a)) methylation is a frequent event in colorectal cancers: prognostic value and relation to mRNA expression and immunoreactivity. J. Cancer Res. Clin. Oncol. 136, 323–331.PubMedCrossRefGoogle Scholar
  19. Pancione M., Sabatino L., Fucci A., Carafa V., Nebbioso A., Forte N. et al. 2010 Epigenetic silencing of peroxisome proliferator-activated receptor gamma is a biomarker for colorectal cancer progression and adverse patients’ outcome. PLoS One 5, e14229.CrossRefGoogle Scholar
  20. Rosman A. S. and Korsten M. A. 2010 Effect of verification bias on the sensitivity of fecal occult blood testing: a meta-analysis. J. Gen. Intern. Med. 25, 1211–1221.PubMedCrossRefGoogle Scholar
  21. Shima K., Morikawa T., Baba Y., Nosho K., Suzuki M., Yamauchi M. et al. 2011 MGMT promoter methylation, loss of expression and prognosis in 855 colorectal cancers. Cancer Causes Control 22, 301–309.PubMedCrossRefGoogle Scholar
  22. Silver A., Sengupta N., Propper D., Wilson P., Hagemann T., Patel A. et al. 2012 A distinct DNA methylation profile associated with microsatellite and chromosomal stable sporadic colorectal cancers. Int. J. Cancer 130, 1082–1092.PubMedCrossRefGoogle Scholar
  23. Veganzones-de-Castro S., Rafael-Fernandez S., Vidaurreta-Lazaro M., de-la-Orden V., Mediero-Valeros B., Fernandez C. et al. 2012 p16 gene methylation in colorectal cancer patients with long-term follow-up. Rev. Esp. Enferm. Dig. 104, 111– 117.PubMedCrossRefGoogle Scholar
  24. Vilkin A., Niv Y., Nagasaka T., Morgenstern S., Levi Z., Fireman Z. et al. 2009 Microsatellite instability, MLH1 promoter methylation, and BRAF mutation analysis in sporadic colorectal cancers of different ethnic groups in Israel. Cancer 115, 760–769.PubMedCrossRefGoogle Scholar
  25. Yi J. M., Dhir M., Van Neste L., Downing S. R., Jeschke J., Glockner S. C. et al. 2011 Genomic and epigenomic integration identifies a prognostic signature in colon cancer. Clin. Cancer Res. 17, 1535–1545.PubMedCrossRefGoogle Scholar
  26. Yiu R., Qiu H., Lee S. H. and Garcia-Aguilar J. 2005 Mechanisms of microsatellite instability in colorectal cancer patients in different age groups. Dis. Colon Rectum 48, 2061–2069.PubMedCrossRefGoogle Scholar

Copyright information

© Indian Academy of Sciences 2013

Authors and Affiliations

    • 1
    • 2
    • 3
    • 4
    • 3
    • 5
    • 6
    • 7
    • 3
  1. 1.Division of Colorectal Surgery, Department of SurgeryTri-Service General Hospital, National Defense Medical CenterTaipeiTaiwan (Republic of China)
  2. 2.Graduate Institute of Life SciencesNational Defense Medical CenterTaipeiTaiwan (Republic of China)
  3. 3.School of Public HealthNational Defense Medical CenterTaipeiTaiwan (Republic of China)
  4. 4.Department of SurgeryLandseed HospitalPingjen City, Tao-YuanTaiwan (Republic of China)
  5. 5.Department of Public Health, College of MedicineFu-Jen Catholic UniversityNew TaipeiTaiwan (Republic of China)
  6. 6.Department of Health Business AdministrationMeiho UniversityPingtungTaiwan (Republic of China)
  7. 7.Department of AnesthesiologyTri-Service General Hospital, National Defense Medical CenterTaipeiTaiwan (Republic of China)

Personalised recommendations