Haplotypes of bovine FoxO1 gene sequence variants and association with growth traits in Qinchuan cattle
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The winged helix or forkhead box (Fox) class of transcription factors constitutes a family of structurally related transcriptional activators that have been identified in species ranging from yeast to human. The first member of this transcription factor class was identified as a nuclear homeotic gene involved in embryonic development in Drosophilamelanogaster (Weigel et al., 1989).
The FoxO family of forkhead transcription factors represents a subfamily within the larger group of Fox transcription factors. Mammalian FoxO proteins (FoxO1, FoxO3a, FoxO4 and FoxO6), which are homologous to Caenorhabditis elegans protein DAF-16, belong to the O (‘other’) class of the Fox superfamily (Kaestner et al., 2000; Barthel et al., 2005). As transcription factors in the nucleus, the primary function of FoxO proteins is to bind to their cognate DNA target sequences as monomers. The cocrystal structure of another Fox protein, HNF-3γ, with DNA shows that there are 14 protein–DNA contacts...
KeywordsFoxO1 gene growth traits haplotype combination Qinchuan cattle sequence variants
This study was supported by the National Natural Science Foundation of China (grant no. 30972080 and 30901023), Agricultural Science and Technology Innovation Projects of Shaanxi province (no. 2012NKC01-13), Program of National Beef Cattle Industrial Technology System (CARS-38).
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