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Diastereoselective Mannich reaction with prolinated MWCNTs as a heterogeneous organo-nanocatalyst

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Abstract

We intended to convert proline as a homogeneous catalyst to a heterogeneous catalyst by prolination of MWCNTs to improve proline efficiency as a catalyst by the ease of separating, catalytic economy, reusability, etc. To reach these goals, we sketched Pro-MWCNT catalyst and characterized it by different analyses such as FT-IR, SEM, EDX, CHNS. The efficiency of this heterogeneous catalyst was investigated and compared with proline homogeneous catalyst in Mannich reaction. The results hold out improvements in stereoselectivity, ease of separating and reusability.

Graphic Abstract

This work represents an efficient and simple method to prepare Prolinated- MWCNTs as a heterogeneous organo-nanocatalyst. Prolinated-MWCNT was characterized by different analyses. The efficiency and catalytic activity of Pro-MWCNTs have investigated in mannich reaction, which has shown higher diastereoselectivity, moderate enantioselectivity, good reusability and high yields versus parent proline catalyst.

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Acknowledgements

The authors gratefully acknowledge the vice-chancellor- Affairs of Research of Ferdowsi University of Mashhad for financial support by (Grant No. 3/47784).

Author information

Correspondence to Hossein Eshghi.

Additional information

This article is dedicated to the memory of, Professor Mehdi Bakavoli, who recently passed away.

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Khoshnevis, M., Eshghi, H. Diastereoselective Mannich reaction with prolinated MWCNTs as a heterogeneous organo-nanocatalyst. J Chem Sci 132, 41 (2020). https://doi.org/10.1007/s12039-020-1740-4

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Keywords

  • Multiwall Carbon Nanotubes
  • L-proline
  • Diastereoselective
  • Mannich reaction
  • Heterogeneous Catalyst