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Detection of hydrogen sulfide using BODIPY based colorimetric and fluorescent on-off chemosensor

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Abstract

A colorimetric and fluorescence turn-off probe 10-(4-azido phenyl)-5,5-difluoro-5h-dipyrrolo[1,2-c:1’,2’-f][1,3,2] diazaborinin-4-ium-5-uide, 1, for selective detection of H2S is reported. The probe displayed a robust decrease in fluorescence intensity with high sensitivity, specificity and least toxicity to detect exogenous H2S and also in live normal human oral fibroblast cells loaded with probe 1. The detection limit of probe 1 being 0.17 µm for H2S.

Graphic abstract

A colorimetric and fluorescence turn-off BODIPY probe 1, for selective detection of exogenous H2S in live normal human oral fibroblast cells loaded with probe 1 and poisonous H2S gas formed under biodegradation in sewage waters and water tanks and corroded pipe lines. The detection limit of probe 1 being 0.17 μM

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Acknowledgements

We thank Prof. S. Mondal, Department of Chemical Sciences, Indian Institute of Science Education and Research, Mohali for X-ray structure analysis. NP acknowledges the support from CSIR [08/003/(0108)/2015-EMR-I], New Delhi for an SRF. Dr. R. S. thanks D. S. Kothari Post-doctoral fellowship (Grant No. F.13-949/2013(BSR)) and Prof. S.S thanks SERB, DST India for funding the project, EMR/2015/001328.

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Correspondence to Sabyasachi Sarkar.

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Paul, N., Sarkar, R., Sarkar, R. et al. Detection of hydrogen sulfide using BODIPY based colorimetric and fluorescent on-off chemosensor. J Chem Sci 132, 21 (2020). https://doi.org/10.1007/s12039-019-1724-4

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Keywords

  • BODIPY
  • H2S sensing
  • Fluorescent probe
  • Cell imaging
  • Naked eye detection