Journal of Chemical Sciences

, 130:125 | Cite as

Silica-coated iron-oxide nanoparticles doped with Gd(III) complexes as potential double contrast agents for magnetic resonance imaging at different field strengths

  • Alexey Stepanov
  • Svetlana Fedorenko
  • Rustem Amirov
  • Irek Nizameev
  • Kirill Kholin
  • Alexandra Voloshina
  • Anastasiya Sapunova
  • Rafael Mendes
  • Mark Rümmeli
  • Thomas Gemming
  • Asiya Mustafina
  • Boris Odintsov
Regular Article


In the present work, we have prepared the \(\sim \)10 nm superparamagnetic iron-oxide nanoparticles by means of high-temperature decomposition of iron oleate precursor. Then they were coated with silica shell to impart water-solubility and an ability to accommodate paramagnetic Gd(III)-based complexes inside silica coating. All of the prepared nanoparticles form stable in time aqueous dispersions and show good negative or/and positive contrasting effect at different magnetic field strengths (0.47, 1.41, 14.1 T). It has been also exemplified that the incorporation of [Gd(TCAS)] complexes into silica shell triggers a significant increase of the transverse relaxivity of the core–shell nanoparticles. The correlation between relaxometric properties and morphology of the obtained nanoparticles was revealed. The non-toxicity of the obtained nanoparticles along with their ability to shorten both transverse and longitudinal relaxation rates of water protons make them good candidates for their use as dual-mode contrast agents in MRI.

Graphical Abstract


Double contrast agents silica nanoparticles longitudinal relaxivity transverse relaxivity 


Supplementary material

12039_2018_1527_MOESM1_ESM.pdf (288 kb)
Supplementary material 1 (pdf 287 KB)


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Copyright information

© Indian Academy of Sciences 2018

Authors and Affiliations

  • Alexey Stepanov
    • 1
  • Svetlana Fedorenko
    • 1
  • Rustem Amirov
    • 2
  • Irek Nizameev
    • 3
  • Kirill Kholin
    • 1
  • Alexandra Voloshina
    • 1
  • Anastasiya Sapunova
    • 1
  • Rafael Mendes
    • 6
  • Mark Rümmeli
    • 4
    • 5
    • 6
  • Thomas Gemming
    • 6
  • Asiya Mustafina
    • 1
  • Boris Odintsov
    • 7
    • 8
  1. 1.Arbuzov Institute of Organic and Physical ChemistryFRC Kazan Scientific Center of RASKazanRussia
  2. 2.Kazan (Volga region) Federal UniversityKazanRussia
  3. 3.Kazan National Research Technological UniversityKazanRussia
  4. 4.Soochow Institute for Energy and Materials Innovations, College of Physics, Optoelectronics and Energy & Collaborative Innovation Center of Suzhou Nano Science and Technology & Suzhou Key Laboratory for Advanced Carbon Materials and Wearable Energy TechnologiesSoochow UniversitySuzhouChina
  5. 5.Centre of Polymer and Carbon MaterialsPolish Academy of SciencesZabrzePoland
  6. 6.IFW DresdenDresdenGermany
  7. 7.Biomedical Imaging Center of the Beckman Institute for Advanced Science and TechnologyUniversity of IllinoisUrbana-ChampaignUSA
  8. 8.Department of BioengineeringUniversity of IllinoisUrbana-ChampaignUSA

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