Ruthenium-bipyridine complex catalyzed C–H alkenylation of arylpyrazole derivatives

  • Sanchari Shome
  • Surya Prakash Singh
Regular Article


Direct dehydrogenative alkenylation of N-arylpyrazoles by acrylates has proven to be efficient under Ru(II) carboxylate complexes SPS-BPY and SPS-DB-BPY catalyst along with \(\hbox {Cu(OAc)}_{2}{\cdot }\hbox {H}_{2}\hbox {O}\) as an oxidant. The reaction was found to be atom-economical and was characterized by a number of substituted N-arylpyrazoles with excellent chemoselectivity. The reaction allowed a direct alkenylation to be performed under the eco-friendly solvent system. The diverse functional group tolerance of this protocol opened up a new insight to the use of ruthenium(II) bipyridine complexes as a productive method for the oxidative heterocoupling of N-arylpyrazole.

Graphical Abstract

Synopsis Ruthenium(II)-Bipyridine catalyst was used for directive C–C alkenylation of arylpyrazoles and aryloxazolines under additive- and co-catalyst-free mild conditions. The comprehensive substrate scope and high chemoselectivity make the protocol versatile. The method prevents the formation of homo-coupled byproducts thereby challenging the traditional alkenylation reactions and opens up a new genre in ruthenium catalysis.


Ru(II) bipyridine alcoholic solvent dialkenylation alkenylarylpyrazoles chemoselectivity acrylate 



SPS and SS thank DST Fast Track Young Scientist Project (CS-83/2012) for funding. SS also thanks AcSIR for PhD registration.

Supplementary material

12039_2018_1478_MOESM1_ESM.pdf (727 kb)
Supplementary material 1 (pdf 727 KB)


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Copyright information

© Indian Academy of Sciences 2018

Authors and Affiliations

  1. 1.Polymers and Functional Materials DivisionCSIR-Indian Institute of Chemical TechnologyHyderabadIndia
  2. 2.Academy of Scientific and Innovative Research (AcSIR New Delhi)New DelhiIndia

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