Journal of Chemical Sciences

, Volume 129, Issue 3, pp 335–341 | Cite as

Synthesis and comparing the antibacterial activities of pyrimidine derivatives

Article
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Abstract

A series of 10 derivatives of 5-(5-amino-1,3,4-thiadiazole-2-yl)-3,4-dihydro-6-methyl-4-phenyl-pyrimidin-2(1H)-one and 10 derivatives of 3,4-dihydro-5-(5-mercapto-4H-1,2,4-triazol-3-yl)-6-methyl-4-phenyl pyrimidin-2(1H)-one have been synthesized. Among the synthesized derivatives, triazole substituted compounds have shown higher antibacterial inhibition when compared to the thiadiazole derivatives. All the structures of the newly synthesized compounds have been characterized by IR, 1H and 13C NMR, GC-MS and CHN analysis. Most of the compounds have shown promising antibacterial activity when compared with the standard drug ciprofloxacin.

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Graphical Abstract

A series of ten derivatives of 5-(5-amino-1,3,4-thiadiazole-2-yl)-3,4-dihydro-6-methyl-4-phenylpyrimidin-2(1H)-one and ten derivatives of 3,4-dihydro-5-(5-mercapto-4H-1,2,4-triazol-3-yl)-6-methyl-4-phenyl pyrimidin-2(1H)-one have been synthesized and structures characterized. Among the synthesized derivatives, triazole substituted compounds have shown higher antibacterial inhibition when compared to the thiadiazole derivatives.

Keywords

5-amino thiadiazole 5-amino triazole hydrazine carbothioamide pseudomonas aeruginosa; staphylococcus aureus escherichia coli. 
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Notes

Acknowledgements

The authors are thankful to the Principal and Research Department of Chemistry, Islamiah College, Vaniyambadi, Vellore district, Tamil Nadu, India for constant encouragement and providing necessary facilities.

Supplementary material

12039_2017_1228_MOESM1_ESM.doc (367 kb)
(DOC 367 KB)
12039_2017_1228_MOESM2_ESM.doc (11.9 mb)
(DOC 11.9 MB)

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Copyright information

© Indian Academy of Sciences 2017

Authors and Affiliations

  1. 1.PG and Research Department of ChemistryIslamiah CollegeVaniyambadiIndia
  2. 2.Thiruvalluvar UniversityVelloreIndia
  3. 3.Priyadarshini Engineering CollegeVaniyambadiIndia
  4. 4.Anna UniversityChennaiIndia

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