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Journal of Chemical Sciences

, Volume 122, Issue 3, pp 443–450 | Cite as

Synthesis and antiulcer activity of 2-[5-substituted-1-H-benzo(d) imidazol-2-yl sulfinyl]methyl-3-substituted quinazoline-4-(3H) ones

  • Avinash PatilEmail author
  • Swastika Ganguly
  • Sanjay Surana
Article

Abstract

2-[5-substituted-1-H-benzo(d)imidazol-2-yl sulfinyl]methyl-3-substituted quinazoline-4-(3H)-one derivatives were synthesized and tested for antiulcer activity against pylorus ligation-induced, aspirin induced and ethanol induced ulcer in rat model. All the synthesized compounds were characterized by using IR, MS and 1H NMR spectral and elemental analysis. The compounds were scramed for their antiulcer activity: compounds 5k and 5n showed higher activity than omeprazole used as standard.

Keywords

Synthesis 4-quinazolinone benzimidazole antiulcer activity 

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Copyright information

© Indian Academy of Sciences 2010

Authors and Affiliations

  • Avinash Patil
    • 1
    Email author
  • Swastika Ganguly
    • 2
  • Sanjay Surana
    • 3
  1. 1.Smt. S.S. Patil College of PharmacyChopdaIndia
  2. 2.Department of Pharmaceutical SciencesBirla Institute of TechnologyMesra, RanchiIndia
  3. 3.R.C. Patel College of PharmacyShirpurIndia

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