Synthesis of some new 4-aryloxmethylcoumarins and examination of their antibacterial and antifungal activities
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A number of new 4-aryloxymethylcoumarins 3 and 5 have been obtained from the reaction of various 4-bromomethylcoumarins with 2-nitro-p-cresol 2 and 2,6-dibromo-p-cresol 4. NOE studies have been carried out on two compounds to ascertain their spatial proximity. p-cresol ethers 7 have been subjected to bromination in chloroform and the position of bromine has been established by diffraction studies. Cleavage of the ether linkage has been observed during an attempted nitration of ethers 7. Antimicrobial activity of all the compounds against five bacterial and five fungal species have been reported.
Keywords4-Bromomethylcoumarins NOE X-ray electrophilic substitution fluorescent antimicrobial
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