Journal of Chemical Sciences

, Volume 121, Issue 4, pp 485–495 | Cite as

Synthesis of some new 4-aryloxmethylcoumarins and examination of their antibacterial and antifungal activities

  • Mahantesha Basanagouda
  • Manohar V. Kulkarni
  • Deepak Sharma
  • Vivek K. Gupta
  • Pranesha
  • P. Sandhyarani
  • Vijaykumar P. Rasal
Article

Abstract

A number of new 4-aryloxymethylcoumarins 3 and 5 have been obtained from the reaction of various 4-bromomethylcoumarins with 2-nitro-p-cresol 2 and 2,6-dibromo-p-cresol 4. NOE studies have been carried out on two compounds to ascertain their spatial proximity. p-cresol ethers 7 have been subjected to bromination in chloroform and the position of bromine has been established by diffraction studies. Cleavage of the ether linkage has been observed during an attempted nitration of ethers 7. Antimicrobial activity of all the compounds against five bacterial and five fungal species have been reported.

Keywords

4-Bromomethylcoumarins NOE X-ray electrophilic substitution fluorescent antimicrobial 

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Copyright information

© Indian Academy of Sciences 2009

Authors and Affiliations

  • Mahantesha Basanagouda
    • 1
  • Manohar V. Kulkarni
    • 1
  • Deepak Sharma
    • 2
  • Vivek K. Gupta
    • 2
  • Pranesha
    • 3
  • P. Sandhyarani
    • 3
  • Vijaykumar P. Rasal
    • 3
  1. 1.Post-Graduate Department of ChemistryKarnatak UniversityDharwadIndia
  2. 2.Post-Graduate Department of PhysicsUniversity of JammuJammuIndia
  3. 3.Department of PharmacologyKLE’s College of PharmacyBelgaumIndia

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