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Deconstructing age reprogramming

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Abstract

It has been proposed that age reprogramming enables old cells to be rejuvenated without passage through an embryonic stage (Singh and Zacouto in J Biosci 35:315–319, 2010). As such, age reprogramming stands apart from the induced pluripotent stem (iPS) and nuclear transfer-embryonic stem (NT-ES) cell therapies where histo-compatible cells are produced only after passage through an embryonic stage. It avoids many of the disadvantages associated with iPS and NT-ES cell therapies. Experimental evidence in support of age reprogramming is burgeoning. Here, we discuss possible new approaches to enhance age reprogramming, which will have considerable benefits for regenerative therapies.

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Acknowledgements

This work was supported by a grant from the Ministry of Education and Science of Russian Federation #14.Y26.31.0024 and Nazarbayev University (Grant No. 090118FD5311).

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Correspondence to Prim B Singh.

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Singh, P.B., Laktionov, P.P. & Newman, A.G. Deconstructing age reprogramming. J Biosci 44, 106 (2019). https://doi.org/10.1007/s12038-019-9923-1

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Keywords

  • Age reprogramming
  • Epigenetic rejuvenation
  • iPS cells
  • reprogramming factors
  • Epigenetic clock
  • eAge