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Journal of Biosciences

, Volume 40, Issue 3, pp 531–537 | Cite as

The potential role of myostatin and neurotransmission genes in elite sport performances

  • L Filonzi
  • N Franchini
  • M Vaghi
  • S Chiesa
  • F Nonnis MarzanoEmail author
Article

Abstract

Elite athletes are those who represent their sport at such major competition as the Olympic Games or World contests. The most outstanding athletes appear to emerge as a result of endogenous biologic characteristics interacting with exogenous influences of the environment, often described as a ‘Nature and Nurture’ struggle. In this work, we assessed the contribution given by 4 genes involved in muscles development (MSTN) and behavioural insights (5HTT, DAT and MAOA) to athletic performances. As for neurotransmission, 5HTT, DAT and MAOA genes have been considered as directly involved in the management of aggressiveness and anxiety.

Genotypes and allelic frequencies of 5HTTLPR, MAOA-u VNTR, DAT VNTR and MSTN K153R were determined in 50 elite athletes and compared with 100 control athletes.

In this work we found a significant correlation between the dopamine transporter genotype 9/9 and allele 9 and elite sport performances. On the contrary, no association was found between muscle development regulation or serotonin pathway and elite performances. Our data, for the first time, suggest a strong role of dopamine neurotransmitter in determining sport success, highlighting the role of emotional control and psycological management to reach high-level performances.

Keywords

Dopamine elite sport performance gene polymorphism myostatin neurotransmission serotonin 

Notes

Acknowledgements

The authors are thankful to all those who collaborated in samples collection or establishing contact with elite athletes: Pasquale Abeti (Track and Field), Alessandro Tombolini and Giuseppe Montenet (ATP Tennis), Federica Maldini (WTA Tennis), Ivan Carminati (English Premiere League Soccer), Dr Massimo Manara (Italian Serie A Soccer), Mariachiara Franchini (Italian Professional Basketball Federation), Andrea Giani (Italian Professional Volleyball League), Dr Alberto Rusconi (European Top 11 Rugby League) and Alessandra Blanchet (Canoeing).

SC benefited from a Postdoctoral grant given by the Portuguese FCT (Fundação Para a Ciência e Tecnologia).

References

  1. Cohen IL, Liu X, Schutz C, White BN, Jenkins EC, Brown WT and Holden JJ 2003 Association of autism severity with monoamine oxidase A functional polymorphism. Clin. Genet. 64 190–197CrossRefPubMedGoogle Scholar
  2. Costa AM, Breitenfeld L, Silva A, Pereira A, Izquierdo M and Marques MC 2012 Genetic inheritance effects on endurance and muscle strength: an update. Sports Med. 42 449–458CrossRefPubMedGoogle Scholar
  3. Deckert J, Catalano M, Syagailo YV, Bosi M, Okladnova O, Di Bella D, Nöthen MM, Maffei P, et al. 1999 Excess of high activity monoamine oxidase A gene promoter alleles in female patients with panic disorder. Hum. Mol. Genet. 8 621–624CrossRefPubMedGoogle Scholar
  4. Druzhevskaya AM, Ahmetov II, Astratenkova IV and Rogozkin VA 2008 Association of the ACTN3 R577X polymorphism with power athlete status in Russians. Eur. J. Appl. Physiol. 103 631–634CrossRefPubMedGoogle Scholar
  5. Ferrell RE, Conte V, Lawrence EC, Roth SM, Hagberg JM and Hurley BF 1999 Frequent sequence variation in the human myostatin (GDF8) gene as a marker for analysis of muscle-related phenotypes. Genomics 62 203–207CrossRefPubMedGoogle Scholar
  6. Filonzi L, Magnani C, Lavezzi AM, Rindi G, Parmigiani S, Bevilacqua G, Matturri L and Nonnis Marzano F 2009 Association of dopamine transporter and monoamine oxidase molecular polymorphisms with sudden infant death syndrome and stillbirth: new insights into the serotonin hypothesis. Neurogenetics 10 65–72CrossRefPubMedGoogle Scholar
  7. Gelernter J, Cubells JF, Kidd JR, Pakstis AJ and Kidd KK 1999 Population studies of polymorphisms of the serotonin transporter protein gene. Am. J. Med. Genet. 88 61–66CrossRefPubMedGoogle Scholar
  8. Gerra G, Garofano L, Pellegrini C, Bosari S, Zaimovic A, Moi G, Avanzini P, Talarico E, et al. 2005 Allelic association of a dopamine transporter gene polymorphism with antisocial behaviour in heroin-dependent patients. Addict. Biol. 10 275–281CrossRefPubMedGoogle Scholar
  9. Grobet L, Martin LJ, Poncelet D, Pirottin D, Brouwers B, Riquet J, Schoeberlein A and Dunner S 1997 A deletion in the bovine myostatin gene causes the double-muscled phenotype in cattle. Nat. Genet. 17 71–74CrossRefPubMedGoogle Scholar
  10. Kambadur R, Sharma M, Smith TPL and Bass JJ 1997 Mutation in myostatin (GDF8) in double muscled Belgian Blue and Piedmontese cattle. Genome Res. 7 910–915PubMedGoogle Scholar
  11. Kostek MA, Angelopoulos TJ, Clarkson PM, Gordon PM, Moyna NM, Visich PS, Zoeller RF, Price TB, et al. 2009 Myostatin and follistatin polymorphisms interact with muscle phenotypes and ethnicity. Med. Sci. Sports Exerc. 41 1063–1071PubMedCentralCrossRefPubMedGoogle Scholar
  12. Lesch KP, Araragi N, Waider J, van den Hove D and Gutknecht L 2012 Targeting brain serotonin synthesis: insights into neurodevelopmental disorders with long-term outcomes related to negative emotionality, aggression and antisocial behaviour. Philos. Trans. R. Soc. Lond. B Biol. Sci. 367 2426–2443PubMedCentralCrossRefPubMedGoogle Scholar
  13. Lin Z and Madras BK 2006 Human genetics and pharmacology of neurotransmitter transporters. Handb. Exp. Pharmacol. 175 327–371CrossRefPubMedGoogle Scholar
  14. Lippi G, Longo UG and Maffulli N 2010 Genetics and sports. Br. Med. Bull. 93 27–47CrossRefPubMedGoogle Scholar
  15. MacArthur DG and North KN 2005 Genes and human elite athletic performance. Hum. Genet. 116 331–339CrossRefPubMedGoogle Scholar
  16. McPherron AC, Lawler AM and Lee SJ 1997 Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. Nature 387 83–90CrossRefPubMedGoogle Scholar
  17. Melke J, Landen M, Baghei F, Rosmond R, Holm G, Björntorp P, Westberg L, Hellstrand M, et al. 2001 Serotonin transporter gene polymorphisms are associated with anxiety-related personality traits in women. Am. J. Med. Genet. 105 458–463CrossRefPubMedGoogle Scholar
  18. Mill J, Asherson P, Browes C, D’Souza U and Craig I 2002 Expression of the dopamine transporter gene is regulated by the 3_UTR VNTR: evidence from brain and lymphocytes using quantitative RT-PCR. Am. J. Med. Genet. 114 975–979CrossRefPubMedGoogle Scholar
  19. Missitzi J, Gentner R, Misitzi A, Geladas N, Politis P, Klissouras V and Classen J 2013 Heritability of motor control and motor learning. Physiol. Rep. 1 e00188PubMedCentralCrossRefPubMedGoogle Scholar
  20. Mosher DS, Quignon P, Bustamante CD, Sutter NB, Mellersh CS, Parker HG and Ostrander EA 2007 A mutation in the myostatin gene increases muscle mass and enhances racing performance in heterozygote dogs. PLoS Genet. 3 e79PubMedCentralCrossRefPubMedGoogle Scholar
  21. Nonnis Marzano F, Maldini M, Filonzi L, Lavezzi AM, Parmigiani S, Magnani C, Bevilacqua G and Matturri L 2008 Genes regulating the serotonin metabolic pathway in the brain stem and their role in the etiopathogenesis of the sudden infant death syndrome. Genomics 91 485–491CrossRefPubMedGoogle Scholar
  22. Ostrander EA, Huson HJ and Ostrander GK 2009 Genetics of athletic performance. Annu. Rev. Genomics Hum. Genet. 10 407–429CrossRefPubMedGoogle Scholar
  23. Pasini A, Sinibaldi L, Paloscia C, Douzgou S, Pitzianti MB, Romeo E, Curatolo P and Pizzuti A 2013 Neurocognitive effects of methylphenidate on ADHD children with different DAT genotypes: a longitudinal open label trial. Eur. J. Paediatr. Neurol. 17 407–414CrossRefPubMedGoogle Scholar
  24. Pavlov KA, Chistiakov DA and Chekhonin VP 2012 Genetic determinants of aggression and impulsivity in humans. J. Appl. Genet. 53 61–82CrossRefPubMedGoogle Scholar
  25. Pokrywka A, Kaliszewski P, Majorczyk E and Zembroń-Łacny A 2013 Genes in sport and doping. Biol. Sport. 30 155–161PubMedCentralCrossRefPubMedGoogle Scholar
  26. Rankinen T, Bray MS, Hagberg JM, Pérusse L, Roth SM, Wolfarth B and Bouchard C 2006 The human gene map for performance and health-relatedness phenotypes: the 2005 update. Med. Sci. Sports Exerc. 38 1863–1888CrossRefPubMedGoogle Scholar
  27. Sabol SZ, Hu S and Hamer D 1998 A functional polymorphism in the monoamine oxidase A gene promoter. Hum. Genet. 103 273–279CrossRefPubMedGoogle Scholar
  28. Santiago C, Ruiz JR, Rodríguez-Romo G, Fiuza-Luces C, Yvert T, Gonazales-Freire M, Gomez-Gallego F, Moran M, et al. 2011 The K153R polymorphism in the myostatin gene and muscle power phenotypes in young, non-athletic men. PLoS One 6 e16323PubMedCentralCrossRefPubMedGoogle Scholar
  29. Schuelke M, Wagner KR, Stolz LE, Hubner C, Riebel T, Kömen W, Braun T and Tobin JF 2004 Myostatin mutation associated with gross muscle hypertrophy in a child. N. Engl. J. Med. 350 2682–2688CrossRefPubMedGoogle Scholar
  30. van Dyck CH, Malison RT, Jacobsen LK, Seibyl JP, Staley JK, Laruelle M, Baldwin RM, Innis RB, et al. 2005 Increased dopamine transporter availability associated with the 9-repeat allele of the SLC6A3 gene. J. Nucl. Med. 46 745–751PubMedGoogle Scholar
  31. Vanderbergh DJ, Persico AM, Hawkins AL, Griffin CA, Li X, Jabs EW and Uhl GR 1992 Human dopamine transporter gene (DAT1) maps to chromosome 5p 15.3 and displays a VNTR. Genomics 14 1104–1106CrossRefGoogle Scholar
  32. Weintraub D, Newberg AB, Cary MS, Siderowf AD, Moberg PJ, Kleiner-Fisman G, Duda JE, Stern MB, et al. 2005 Striatal dopamine transporter imaging correlates with anxiety and depression symptoms in Parkinson's disease. J. Nucl. Med. 46 227–232PubMedGoogle Scholar

Copyright information

© Indian Academy of Sciences 2015

Authors and Affiliations

  • L Filonzi
    • 1
  • N Franchini
    • 1
  • M Vaghi
    • 1
  • S Chiesa
    • 1
  • F Nonnis Marzano
    • 1
    Email author
  1. 1.Department of Life SciencesUniversity of ParmaParmaItaly

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