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Journal of Biosciences

, Volume 39, Issue 4, pp 595–603 | Cite as

Insights into brain development and disease from neurogenetic analyses in Drosophila melanogaster

  • Heinrich Reichert
Article
  • 144 Downloads

Abstract

Groundbreaking work by Obaid Siddiqi has contributed to the powerful genetic toolkit that is now available for studying the nervous system of Drosophila. Studies carried out in this powerful neurogenetic model system during the last decade now provide insight into the molecular mechanisms that operate in neural stem cells during normal brain development and during abnormal brain tumorigenesis. These studies also provide strong support for the notion that conserved molecular genetic programs act in brain development and disease in insects and mammals including humans.

Keywords

Asymmetric division lineage neuroblast SWI/SNF complex transit amplifying cell tumour 

Notes

Acknowledgements

The author acknowledges the support of the Swiss NSF.

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Copyright information

© Indian Academy of Sciences 2014

Authors and Affiliations

  1. 1.Biozentrum, University of BaselBaselSwitzerland

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