Journal of Biosciences

, 34:523 | Cite as

Human pancreatic islet progenitor cells demonstrate phenotypic plasticity in vitro

  • Maithili P. Dalvi
  • Malati R. Umrani
  • Mugdha V. Joglekar
  • Anandwardhan A. Hardikar


Phenotypic plasticity is a phenomenon that describes the occurrence of 2 or more distinct phenotypes under diverse conditions. This article discusses the work carried out over the past few years in understanding the potential of human pancreatic islet-derived progenitors for cell replacement therapy in diabetes. The phenotypic plasticity exhibited by pancreatic progenitors during reversible epithelial-to-mesenchymal transition (EMT) and possible role of microRNAs in regulation of this process is also presented herein.


Differentiation EMT pancreas plasticity progenitor 


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Copyright information

© Indian Academy of Sciences 2009

Authors and Affiliations

  • Maithili P. Dalvi
    • 1
  • Malati R. Umrani
    • 1
  • Mugdha V. Joglekar
    • 1
  • Anandwardhan A. Hardikar
    • 1
  1. 1.Stem Cells and Diabetes Section, Lab 12National Center for Cell SciencePuneIndia

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