Human pancreatic islet progenitor cells demonstrate phenotypic plasticity in vitro
- 83 Downloads
Phenotypic plasticity is a phenomenon that describes the occurrence of 2 or more distinct phenotypes under diverse conditions. This article discusses the work carried out over the past few years in understanding the potential of human pancreatic islet-derived progenitors for cell replacement therapy in diabetes. The phenotypic plasticity exhibited by pancreatic progenitors during reversible epithelial-to-mesenchymal transition (EMT) and possible role of microRNAs in regulation of this process is also presented herein.
KeywordsDifferentiation EMT pancreas plasticity progenitor
- Moriscot C, de Fraipont F, Richard M J, Marchand M, Savatier P, Bosco D, Favrot M and Benhamou P Y 2005 Human bone marrow mesenchymal stem cells can express insulin and key transcription factors of the endocrine pancreas developmental pathway upon genetic and/or microenvironmental manipulation in vitro; Stem Cells 23 594–603CrossRefPubMedGoogle Scholar
- Noguchi H 2001 Stem cells for treatment of diabetes; Endocrinol. J. 54 7–16Google Scholar
- Shapiro A M, Ricordi C, Hering B J, Auchincloss H, Lindblad R, Robertson R P, Secchi A, Brendel M D, Berney T, Brennan D C, Cagliero E, Alejandro R, Ryan E A, DiMercurio B, Morel P, Polonsky, K S, Reems J A, Bretzel R G, Bertuzzi F, Froud T, Kandaswamy R, Sutherland D E, Eisenbarth G, Segal M, Preiksaitis J, Korbutt G S, Barton F B, Viviano L, Seyfert-Margolis V, Bluestone J and Lakey J R 2006 International trial of the Edmonton protocol for islet transplantation; N. Engl. J. Med. 355 1318–1330CrossRefPubMedGoogle Scholar