Journal of Biosciences

, 33:539

Brucellosis in India — a review

Article

DOI: 10.1007/s12038-008-0072-1

Cite this article as:
Mantur, B.G. & Amarnath, S.K. J Biosci (2008) 33: 539. doi:10.1007/s12038-008-0072-1

Abstract

Brucellosis is an important re-emerging zoonosis with a worldwide distribution. It is still an uncontrolled serious public health problem in many developing countries including India. Brucellosis in India is yet a very common but often neglected disease. Currently, Brucella melitensis accounts for most recorded cases globally with cattle emerging as a important reservoir with the few cases of B. suis. Isolated cases of non-terrestrial brucellosis and continuing transmission from wild animals have raised important epidemiological issues. Routine serological surveillance along with high clinical suspicion and screening of family members of index cases would be essential in delineating the real magnitude of human brucellosis in endemic countries. Increased business and leisure travel to endemic countries have led to diagnostic challenge in non-endemic areas. Laboratory testing is indispensable for diagnosis. Advances in newer rapid, sensitive, and specific testing methodologies and alternate treatment strategies are urgently needed. A safe and effective vaccine in human is not yet available. Prevention is dependent upon increasing public awareness through health education programmes and safe livestock practices. Active co-operation between health and veterinary services should be promoted. This review collates world literature and its impact to the discovery, isolation and diagnosis and epidemiology along with the control measures adapted in the Indian scenario.

Keywords

Brucella spp. epidemiology protean manifestations serological surveillance livestock vaccination 

Abbreviations used

ELISA

enzyme linked immunosorbent assay

LPS

lipopolysaccharide

2ME

2 mercaptoethanol

PCR

polymerase chain reaction

PUO

pyrexia of unknown origin

RBPT

rose Bengal plate agglutination test

SAT

Standard tube agglutination test

S-LPS

smooth-lipopolysaccharide

TMP/SMX

trimethoprim/sulfamethoxazole

Copyright information

© Indian Academy of Sciences 2008

Authors and Affiliations

  1. 1.Department of MicrobiologyBelgaum Institute of Medical SciencesBelgaumIndia
  2. 2.Manipal Cure and CareBangaloreIndia

Personalised recommendations