Journal of Biosciences

, Volume 32, Issue 3, pp 579–584 | Cite as

Mechanisms of HSP72 release

  • Alexzander Asea
Article
First Online:

Abstract

Currently two mechanisms are recognized by which heat shock proteins (HSP) are released from cells; a passive release mechanism, including necrotic cell death, severe blunt trauma, surgery and following infection with lytic viruses, and an active release mechanism which involves the non classical protein release pathway. HSPs are released both as free HSP and within exosomes. This review covers recent findings on the mechanism by which stress induces the release of HSP72 into the circulation and the biological significance of circulating HSP72 to host defense against disease.

Keywords

Cancer Chaperokine heat shock proteins inflammation receptors signal transduction 

Abbreviations used

APC

antigen presenting cells

eHSP72

extracellular HSP72

Hsc73

constitutive seventy-kilo Dalton heat shock protein

HSP72

inducible seventy-kilo Dalton heat shock protein

IFN-γ

interferon-gamma

iHSP72

intracellular HSP72

TLR

toll-like receptors

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Copyright information

© Indian Academy of Sciences 2007

Authors and Affiliations

  • Alexzander Asea
    • 1
  1. 1.Division of Investigative PathologyScott & White Clinic and Texas A&M University System Health Science Center College of MedicineTempleUSA

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