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Molecular Neurobiology

, Volume 56, Issue 7, pp 4960–4979 | Cite as

Development of Cortical Pyramidal Cell and Interneuronal Dendrites: a Role for Kainate Receptor Subunits and NETO1

  • Alexander Jack
  • Mohammad I. K. Hamad
  • Steffen Gonda
  • Sebastian Gralla
  • Steffen Pahl
  • Michael Hollmann
  • Petra WahleEmail author
Article

Abstract

During neuronal development, AMPA receptors (AMPARs) and NMDA receptors (NMDARs) are important for neuronal differentiation. Kainate receptors (KARs) are closely related to AMPARs and involved in the regulation of cortical network activity. However, their role for neurite growth and differentiation of cortical neurons is unclear. Here, we used KAR agonists and overexpression of selected KAR subunits and their auxiliary neuropilin and tolloid-like proteins, NETOs, to investigate their influence on dendritic growth and network activity in organotypic cultures of rat visual cortex. Kainate at 500 nM enhanced network activity and promoted development of dendrites in layer II/III pyramidal cells, but not interneurons. GluK2 overexpression promoted dendritic growth in pyramidal cells and interneurons. GluK2 transfectants were highly active and acted as drivers for network activity. GluK1 and NETO1 specifically promoted dendritic growth of interneurons. Our study provides new insights for the roles of KARs and NETOs in the morphological and physiological development of the visual cortex.

Keywords

Rat neocortex Postnatal development Dendritogenesis Glutamate receptors GluK2 NETO 

Notes

Acknowledgements

We thank Andrea Räk, Sabine Schönfelder, and Christian Riedel for technical support. We thank Prof. Nathalie Strutz-Seebohm, University Münster, for providing the TTBK2-KD plasmid. We thank Prof. Andreas Reiner, Ruhr University Bochum, for discussion. We thank Bente Janssen-Weets and Felix Burgmann for help with reconstructions during their BSc thesis work.

Author Contribution

AJ, MIKH, and PW designed experiments. AJ, MIKH, SG, SG, SP, and PW performed experiments. AJ and PW did the data management and interpretation. AJ and PW wrote the manuscript. MH commented on the manuscript. All authors approved the final version.

Funding Information

Supported by Deutsche Forschungsgemeinschaft grants WA 541/9-1 and 541/9-2.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they do not have any conflict of interest.

Supplementary material

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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Faculty for Biology and Biotechnology ND 6/72, Developmental NeurobiologyRuhr University BochumBochumGermany
  2. 2.Medical Faculty, Neuroanatomy and Molecular Brain ResearchRuhr University BochumBochumGermany
  3. 3.Faculty of Chemistry and Biochemistry, Biochemistry I—Receptor BiochemistryRuhr University BochumBochumGermany

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