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Molecular Neurobiology

, Volume 55, Issue 7, pp 5672–5688 | Cite as

Field Synopsis and Re-analysis of Systematic Meta-analyses of Genetic Association Studies in Multiple Sclerosis: a Bayesian Approach

  • Jae Hyon Park
  • Joo Hi Kim
  • Kye Eun Jo
  • Se Whan Na
  • Michael Eisenhut
  • Andreas Kronbichler
  • Keum Hwa Lee
  • Jae Il ShinEmail author
Article

Abstract

To provide an up-to-date summary of multiple sclerosis-susceptible gene variants and assess the noteworthiness in hopes of finding true associations, we investigated the results of 44 meta-analyses on gene variants and multiple sclerosis published through December 2016. Out of 70 statistically significant genotype associations, roughly a fifth (21%) of the comparisons showed noteworthy false-positive rate probability (FPRP) at a statistical power to detect an OR of 1.5 and at a prior probability of 10−6 assumed for a random single nucleotide polymorphism. These associations (IRF8/rs17445836, STAT3/rs744166, HLA/rs4959093, HLA/rs2647046, HLA/rs7382297, HLA/rs17421624, HLA/rs2517646, HLA/rs9261491, HLA/rs2857439, HLA/rs16896944, HLA/rs3132671, HLA/rs2857435, HLA/rs9261471, HLA/rs2523393, HLA-DRB1/rs3135388, RGS1/rs2760524, PTGER4/rs9292777) also showed a noteworthy Bayesian false discovery probability (BFDP) and one additional association (CD24 rs8734/rs52812045) was also noteworthy via BFDP computation. Herein, we have identified several noteworthy biomarkers of multiple sclerosis susceptibility. We hope these data are used to study multiple sclerosis genetics and inform future screening programs.

Keywords

Multiple sclerosis FPRP BFDP Gene variant Meta-analysis 

Notes

Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Compliance with Ethical Standards

Manuscript is not under consideration for publication elseware and all named authors have agreed to its submission. No patients were involved in setting the research question or outcome measures, nor were they involved in developing plans for design or implementation of the study.

Disclosures

The authors declare no financial or non-financial conflict of interest.

Supplementary material

12035_2017_773_MOESM1_ESM.docx (165 kb)
ESM 1 (DOCX 165 kb)

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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  1. 1.Severance HospitalYonsei University College of MedicineSeoulRepublic of Korea
  2. 2.Yonsei University Wonju College of MedicineSeoulRepublic of Korea
  3. 3.College of MedicineUniversity of DebrecenDebrecenHungary
  4. 4.Department of PediatricsLuton & Dunstable University Hospital NHS Foundation TrustLutonUK
  5. 5.Department of Internal Medicine IVMedical University InnsbruckInnsbruckAustria
  6. 6.Department of PediatricsYonsei University College of MedicineSeoulRepublic of Korea

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