Evaluation of Possible Consequences of Zika Virus Infection in the Developing Nervous System

  • Lais Takata Walter
  • Guilherme Shigueto Vilar Higa
  • Juliane Midori Ikebara
  • Danila Vedovello
  • Felipe Scassi Salvador
  • Silvia Honda Takada
  • Erika Reime Kinjo
  • Benjamin J. Whalley
  • Márcia Aparecida Sperança
  • Alexandre Hiroaki Kihara
Article

DOI: 10.1007/s12035-017-0442-5

Cite this article as:
Walter, L.T., Higa, G.S.V., Ikebara, J.M. et al. Mol Neurobiol (2017). doi:10.1007/s12035-017-0442-5

Abstract

The Zika virus (ZIKV) outbreak that occurred in the northeast of Brazil in 2015 led to alarming numbers of babies born with microcephaly in this region. Since then, several studies have evaluated the relationship between ZIKV infection and development of the malformation although the specific mechanistic interaction between ZIKV and human physiological processes that ultimately manifest as microcephaly remains debated. Importantly, most current studies did not consider the specificities of the biology and life cycle of ZIKV. As a consequence, specificities of the infection on the developing central nervous system (CNS) were frequently disregarded. In order to begin to address this important gap in our knowledge, we have collated and critically reviewed the existing evidence in this area to identify any emerging consensus on this topic and thereafter describe possible mechanisms by which ZIKV infection could interfere with specific processes of CNS development, such as neuronal proliferation, and the complex interactions of immature neurons with radial glial cells. With this, we were able to present the current knowledge on this important topic in the neurobiology field.

Keywords

Neurodevelopment Disease Infection Virulence Microcephaly 

Funding information

Funder NameGrant NumberFunding Note
Fundação de Amparo à Pesquisa do Estado de São Paulo
  • 2015/04495-0
  • 2014/15018-5
  • 2014/16711-6
  • 2012/03583-4
  • 2014/04568-4
Conselho Nacional de Desenvolvimento Científico e Tecnológico
  • 308608/2014-3

Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Lais Takata Walter
    • 1
  • Guilherme Shigueto Vilar Higa
    • 1
    • 2
  • Juliane Midori Ikebara
    • 1
  • Danila Vedovello
    • 3
  • Felipe Scassi Salvador
    • 4
  • Silvia Honda Takada
    • 1
  • Erika Reime Kinjo
    • 1
  • Benjamin J. Whalley
    • 5
  • Márcia Aparecida Sperança
    • 3
  • Alexandre Hiroaki Kihara
    • 1
    • 2
  1. 1.Núcleo de Cognição e Sistemas Complexos, Centro de Matemática, Computação e CogniçãoUniversidade Federal do ABCSão Bernardo do CampoBrazil
  2. 2.Departamento de Fisiologia e Biofísica, Instituto de Ciências BiomédicasUniversidade de São PauloSão PauloBrazil
  3. 3.Centro de Ciências Naturais e HumanasUniversidade Federal do ABCSão Bernardo do CampoBrazil
  4. 4.Laboratório de VirologiaInstituto de Medicina Tropical da Universidade de São PauloSão PauloBrazil
  5. 5.School of Chemistry, Food and Nutritional Sciences, and PharmacyUniversity of Reading, WhiteknightsBerkshireUK

Personalised recommendations