Molecular Neurobiology

, Volume 55, Issue 3, pp 1831–1846 | Cite as

The Involvement of the Myelin-Associated Inhibitors and Their Receptors in CNS Plasticity and Injury

  • Anthony G. Boghdadi
  • Leon Teo
  • James A. BourneEmail author


The limited capacity for the central nervous system (CNS) to repair itself was first described over 100 years ago by Spanish neuroscientist Ramon Y. Cajal. However, the exact mechanisms underlying this failure in neuronal regeneration remain unclear and, as such, no effective therapeutics yet exist. Numerous studies have attempted to elucidate the biochemical and molecular mechanisms that inhibit neuronal repair with increasing evidence suggesting that several inhibitory factors and repulsive guidance cues active during development actually persist into adulthood and may be contributing to the inhibition of repair. For example, in the injured adult CNS, there are various inhibitory factors that impede the outgrowth of neurites from damaged neurons. One of the most potent of these neurite outgrowth inhibitors is the group of proteins known as the myelin-associated inhibitors (MAIs), present mainly on the membranes of oligodendroglia. Several studies have shown that interfering with these proteins can have positive outcomes in CNS injury models by promoting neurite outgrowth and improving functional recovery. As such, the MAIs, their receptors, and downstream effectors are valid drug targets for the treatment of CNS injury. This review will discuss the current literature on MAIs in the context of CNS development, plasticity, and injury. Molecules that interfere with the MAIs and their receptors as potential candidates for the treatment of CNS injury will additionally be introduced in the context of preclinical and clinical trials.


Neuroplasticity Glycoprotein Oligodendrocyte Neurite outgrowth inhibitor Stroke 



The authors wish to acknowledge and thank C. Bernard for his useful comments on earlier versions of the article. A National Health and Medical Research Council (NHMRC) Senior Research Fellowship (APP1077677) supports JAB, and AGB is supported by an Australian Postgraduate Award (APA) Scholarship. An NHMRC Project Grant (APP108197) supported this work. The Australian Regenerative Medicine Institute is supported by grants from the State Government of Victoria and the Australian Government.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflicts of interest.


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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Anthony G. Boghdadi
    • 1
  • Leon Teo
    • 1
  • James A. Bourne
    • 1
    Email author
  1. 1.Australian Regenerative Medicine InstituteMonash UniversityClaytonAustralia

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