Molecular Neurobiology

, Volume 54, Issue 5, pp 3506–3527 | Cite as

A Review on Microdialysis Calibration Methods: the Theory and Current Related Efforts

  • Chun Min Kho
  • Siti Kartini Enche Ab Rahim
  • Zainal Arifin Ahmad
  • Norazharuddin Shah AbdullahEmail author


Microdialysis is a sampling technique first introduced in the late 1950s. Although this technique was originally designed to study endogenous compounds in animal brain, it is later modified to be used in other organs. Additionally, microdialysis is not only able to collect unbound concentration of compounds from tissue sites; this technique can also be used to deliver exogenous compounds to a designated area. Due to its versatility, microdialysis technique is widely employed in a number of areas, including biomedical research. However, for most in vivo studies, the concentration of substance obtained directly from the microdialysis technique does not accurately describe the concentration of the substance on-site. In order to relate the results collected from microdialysis to the actual in vivo condition, a calibration method is required. To date, various microdialysis calibration methods have been reported, with each method being capable to provide valuable insights of the technique itself and its applications. This paper aims to provide a critical review on various calibration methods used in microdialysis applications, inclusive of a detailed description of the microdialysis technique itself to start with. It is expected that this article shall review in detail, the various calibration methods employed, present examples of work related to each calibration method including clinical efforts, plus the advantages and disadvantages of each of the methods.


Microdialysis Calibration method Relative recovery Absolute recovery 



The authors gratefully acknowledge the endless and unreserved support provided by the School of Materials and Mineral Resources Engineering (SMMRE), Universiti Sains Malaysia (USM), especially in terms of funding, through USM’s RUI research grant (No. 1001/PBAHAN/814177). The authors also would like express their gratitude to the Ministry of Higher Education (MOHE) Malaysia, through the MyBrain15 Program (Ref: 890529115391/MyPhD) for financial support. The authors also thank BRAINetwork, USM, and Universiti Malaysia Perlis (UniMAP) through the School of Bioprocess Engineering and the Faculty of Engineering Technology for their excellent facilities and technical assistance.


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Chun Min Kho
    • 1
  • Siti Kartini Enche Ab Rahim
    • 2
  • Zainal Arifin Ahmad
    • 1
  • Norazharuddin Shah Abdullah
    • 1
    Email author
  1. 1.Structural Materials Niche Area, School of Materials and Mineral Resources EngineeringUniversiti Sains MalaysiaNibong TebalMalaysia
  2. 2.Department of Chemical Engineering Technology, Faculty of Engineering TechnologyUniversiti Malaysia PerlisPadang BesarMalaysia

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