Molecular Neurobiology

, Volume 54, Issue 2, pp 1440–1455 | Cite as

Nrf2 Weaves an Elaborate Network of Neuroprotection Against Stroke

  • Shuai Jiang
  • Chao Deng
  • Jianjun Lv
  • Chongxi Fan
  • Wei Hu
  • Shouyin Di
  • Xiaolong Yan
  • Zhiqiang Ma
  • Zhenxing LiangEmail author
  • Yang YangEmail author


Nuclear factor erythroid 2-related factor 2 (Nrf2) is a neuroprotective transcription factor that has recently attracted increased attention. Stroke, a common and serious neurological disease, is currently a leading cause of death in the USA so far. It is therefore of vital importance to explore how Nrf2 behaves in stroke. In this review, we first introduce the structural features of Nrf2 and Kelch-like ECH-associated protein 1 (Keap1) and briefly depict the activation, inactivation, and regulation processes of the Nrf2 pathway. Next, we discuss the physiopathological mechanisms, upstream modulators, and downstream targets of the Nrf2 pathway. Following this background, we expand our discussion to the roles of Nrf2 in ischemic and hemorrhagic stroke and provide several potential future directions. The information presented here may be useful in the design of future experimental research and increase the likelihood of using Nrf2 as a therapeutic target for stroke in the future.


Nuclear factor erythroid 2-related factor 2 Oxidative stress Ischemia Hemorrhage 



This work was supported by the National Natural Science Foundation of China (81500263) and China Postdoctoral Science Foundation (2015M572681).


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Shuai Jiang
    • 1
    • 2
  • Chao Deng
    • 3
  • Jianjun Lv
    • 4
  • Chongxi Fan
    • 5
  • Wei Hu
    • 4
  • Shouyin Di
    • 4
  • Xiaolong Yan
    • 4
  • Zhiqiang Ma
    • 4
  • Zhenxing Liang
    • 1
    Email author
  • Yang Yang
    • 1
    • 4
    Email author
  1. 1.Department of Cardiothoracic SurgeryThe First Affiliated Hospital of Zhengzhou UniversityZhengzhouChina
  2. 2.Department of Aerospace MedicineThe Fourth Military Medical UniversityXi’anChina
  3. 3.Department of Cardiovascular Surgery, Xijing HospitalThe Fourth Military Medical UniversityXi’anChina
  4. 4.Department of Biomedical EngineeringThe Fourth Military Medical UniversityXi’anChina
  5. 5.Department of Thoracic Surgery, Tangdu HospitalThe Fourth Military Medical UniversityXi’anChina

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