Molecular Neurobiology

, Volume 53, Issue 9, pp 6557–6567 | Cite as

The Effects of Inhaled Pimpinella peregrina Essential Oil on Scopolamine-Induced Memory Impairment, Anxiety, and Depression in Laboratory Rats

  • Emel Aydin
  • Lucian Hritcu
  • Gulden Dogan
  • Sukru Hayta
  • Eyup Bagci
Article

Abstract

In the present study, we identified the effects of inhaled Pimpinella peregrina essential oil (1 and 3 %, for 21 continuous days) on scopolamine-induced memory impairment, anxiety, and depression in laboratory rats. Y-maze and radial arm-maze tests were used for assessing memory processes. Also, the anxiety and depressive responses were studied by means of the elevated plus-maze and forced swimming tests. The scopolamine alone-treated rats exhibited the following: decrease of the spontaneous alternation percentage in Y-maze test, increase of the number of working and reference memory errors in radial arm-maze test, along with decrease of the exploratory activity, the percentage of the time spent and the number of entries in the open arm within elevated plus-maze test and decrease of swimming time and increase of immobility time within forced swimming test. Inhalation of the P. peregrina essential oil significantly improved memory formation and exhibited anxiolytic- and antidepressant-like effects in scopolamine-treated rats. Our results suggest that the P. peregrina essential oil inhalation ameliorates scopolamine-induced memory impairment, anxiety, and depression. Moreover, studies on the P. peregrina essential oil may open a new therapeutic window for the prevention of neurological abnormalities closely related to Alzheimer’s disease.

Keywords

Pimpinella peregrina essential oil Scopolamine Memory Anxiety Depression Alzheimer’s disease 

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Emel Aydin
    • 1
  • Lucian Hritcu
    • 2
  • Gulden Dogan
    • 1
  • Sukru Hayta
    • 3
  • Eyup Bagci
    • 1
  1. 1.Department of Biology, Faculty of ScienceFirat UniversityElazigTurkey
  2. 2.Department of BiologyAlexandru Ioan Cuza University of IasiIasiRomania
  3. 3.Faculty of Engineering and ArchitectureBitlis Eren UniversityBitlisTurkey

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