Erratum to: Local Interleukin-18 System in the Basolateral Amygdala Regulates Susceptibility to Chronic Stress

Erratum to: Mol Neurobiol

DOI 10.1007/s12035-016-0052-7

The article unfortunately have serious errors in Figures 2 and 5 captions. With these, the authors hereby publish the correct captions.

Fig. 2 Expression of IL18 and IL18 receptors in the BLA. a Photomicrograph showing the location (red rectangle) of high magnification images (b, c, f, g) and the approximate area in the BLA used for quantifications (blue circle). CeA central amygdala, BLA basolateral amygdala. Scale bar = 200 μm. b-e Photomicrographs showing the co-staining of proIL18 and GAD67 (b), and proIL18 and Glu4 (c) in the BLA of mice treated with 2 h × 14 d RST. Venn diagrams for the quantification of co-localization of proIL18 and GAD67 (d) and proIL18 and Glu4 (e), and the number of counted cells of each marker. f-i Photomicrographs showing the co-staining of IL18Rα and GAD67 (f), and IL18Rα and Glu4 (g) in the BLA of mice treated with 2 h × 14 d RST. Venn diagrams for the quantification of co-localization of IL18Rα and GAD67 (h) and IL18Rα and Glu4 (i), and the number of counted cells of each marker. Scale bars in (c, g) = 20 μm.

Fig. 5 NF-kB KO mice were resilient to chronic stress that promotes depression-like behaviors. a Experimental design for treatment with 2 h × 14 d RST and subsequent behavioral tests. Behavioral tests were performed in the order of the sociability test, TST, FST, and NSF. b–e Social interaction levels in the U-field assay (b), immobility time in the TST (c) and FST (d), and latency to eating in the NSF test (e) of NF-kB KO mice and WTcontrols. n = 7–9. f Experimental design for foot-shock treatment for 1 h daily for 7 days and subsequent behavioral tests. Behavioral tests were performed on post-stress days 1–3 in the sequence of the sociability test, TST, and FST. The sucrose preference test was performed independently from the other tests. g–k Sucrose intake in the sucrose preference test (g), social interactions in the U-field assay (h), immobility times in the TST (i) and FST (j), and latency to eating in the NSF test (k) among NF-kB KO mice and WT controls. n = 8–12. l Realtime PCR data showing the downregulation of Hcrt, MCH, OXT, AVP, and TRH in the amygdala of NF-kB p50 KO (NF-kB KO) mice. The downregulation of Hcrt, MCH, and OXT were significant. n = 6 animals for each, four repeats of PCR. m Real-time PCR data showing the expression levels of G9a in the amygdala 3 days after siRNA injection, of naïve normal mice injected with siRNA-control (CON-siCON) or mice subjected to 2 h × 14 d RST, followed by injection of siRNA-control (RST-siCON), siRNA-IL18 (RST-siIL18), siRNA-IL18Rα (RSTT-siIL18Ra), siRNA-NF-kB (RST-siNF-kB), or siRNA-STAT3 (RST-siSTAT3). n = 6 animals for each, four repeats of PCR. n Real-time PCR data showing the expression levels of G9a in the amygdala of IL18 KO mice (IL18 KO) or NF-kB p50 KO mice (NF-kB KO). n = 6 animals for each, four repeats of PCR. Data are presented as mean ± SEM. * and ** denote the difference between indicated groups (b–e, g–k) or from WTcontrol (l) and CON-siCON (m) at p < 0.05 and p < 0.01, respectively. # and ## denote the difference from RST-siCON (m) at p < 0.05 and p < 0.01, respectively (Student’s t test, one-way or two-way ANOVA and Newman-Keuls post hoc test).