Molecular Neurobiology

, Volume 53, Issue 9, pp 6501–6510 | Cite as

Meta-analysis of the Association between Alzheimer Disease and Variants in GAB2, PICALM, and SORL1

  • Ziran Wang
  • Hongyan Lei
  • Mei Zheng
  • Yuxin Li
  • Yansen Cui
  • Fang Hao


The genetic variants play a crucial role in the pathogenesis of Alzheimer’s disease (AD), while the relationships of specific single nucleotide polymorphisms (SNPs) with AD are still controversial. We performed the meta-analysis to obtain a more precise estimation of whether growth factor receptor-bound protein-associated binding protein 2 (GAB2), phosphatidylinositol binding clathrin assembly protein (PICALM), and sortilin-related receptor (SORL1) variants are associated with AD. Databases including PubMed, Embase, and Cochrane Library were searched to find relevant studies. Cochran’s Q-statistic and I 2 were used to assess the heterogeneity among the included studies. Odds ratios (OR) and 95 % confidence intervals (95 % CIs) were conducted to evaluate the association between the SNP and the susceptibility to AD. Publication bias was estimated by funnel plots. All of the statistical analyses were implemented using R Version 3.2.1 software. A total of 35 case-control studies involving 15 SNPs were included. There was no significant association between SNPs of GAB2 rs2373115 (G > T) and PICALM rs541458 (C > T) and AD. The allele T of rs3851179 in PICALM was associated with a 13 % increase in the risk of AD. Seven SNPs on SORL1 were significantly associated with AD. Four SNPs, including rs1010159*T, rs641120*A, rs668387*T, and rs689021*A, were associated with a decreased risk of AD, while the other three SNPs, including rs12285364*T, rs2070045*G, and rs2282649*T, were all associated with an increased risk of AD. The results of the present study suggested that multiple gene variants were associated with AD. The SNP of rs3851179 (PICALM), rs12285364 (SORL1), rs2070045 (SORL1), and rs2282649 (SORL1) was associated with an increased risk of AD, whereas SORL1 rs1010159, rs641120, rs668387, and rs689021 were associated with a decreased risk of AD.


Alzheimer’s disease Single nucleotide polymorphisms PICALM SORL1 GAB2 


Conflict of interest

The authors declare that they have no competing interests.

Supplementary material

12035_2015_9546_MOESM1_ESM.docx (40 kb)
ESM 1 (DOCX 40 kb)


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Ziran Wang
    • 1
  • Hongyan Lei
    • 1
  • Mei Zheng
    • 1
  • Yuxin Li
    • 1
  • Yansen Cui
    • 1
  • Fang Hao
    • 2
  1. 1.Emergency DepartmentLinyi People’s HospitalLinyiChina
  2. 2.Department of NeurologyLiaocheng People’s HospitalLiaochengChina

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