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Molecular Neurobiology

, Volume 53, Issue 9, pp 6501–6510 | Cite as

Meta-analysis of the Association between Alzheimer Disease and Variants in GAB2, PICALM, and SORL1

  • Ziran Wang
  • Hongyan Lei
  • Mei Zheng
  • Yuxin Li
  • Yansen Cui
  • Fang Hao
Article

Abstract

The genetic variants play a crucial role in the pathogenesis of Alzheimer’s disease (AD), while the relationships of specific single nucleotide polymorphisms (SNPs) with AD are still controversial. We performed the meta-analysis to obtain a more precise estimation of whether growth factor receptor-bound protein-associated binding protein 2 (GAB2), phosphatidylinositol binding clathrin assembly protein (PICALM), and sortilin-related receptor (SORL1) variants are associated with AD. Databases including PubMed, Embase, and Cochrane Library were searched to find relevant studies. Cochran’s Q-statistic and I 2 were used to assess the heterogeneity among the included studies. Odds ratios (OR) and 95 % confidence intervals (95 % CIs) were conducted to evaluate the association between the SNP and the susceptibility to AD. Publication bias was estimated by funnel plots. All of the statistical analyses were implemented using R Version 3.2.1 software. A total of 35 case-control studies involving 15 SNPs were included. There was no significant association between SNPs of GAB2 rs2373115 (G > T) and PICALM rs541458 (C > T) and AD. The allele T of rs3851179 in PICALM was associated with a 13 % increase in the risk of AD. Seven SNPs on SORL1 were significantly associated with AD. Four SNPs, including rs1010159*T, rs641120*A, rs668387*T, and rs689021*A, were associated with a decreased risk of AD, while the other three SNPs, including rs12285364*T, rs2070045*G, and rs2282649*T, were all associated with an increased risk of AD. The results of the present study suggested that multiple gene variants were associated with AD. The SNP of rs3851179 (PICALM), rs12285364 (SORL1), rs2070045 (SORL1), and rs2282649 (SORL1) was associated with an increased risk of AD, whereas SORL1 rs1010159, rs641120, rs668387, and rs689021 were associated with a decreased risk of AD.

Keywords

Alzheimer’s disease Single nucleotide polymorphisms PICALM SORL1 GAB2 

Notes

Conflict of interest

The authors declare that they have no competing interests.

Supplementary material

12035_2015_9546_MOESM1_ESM.docx (40 kb)
ESM 1 (DOCX 40 kb)

References

  1. 1.
    Bagyinszky E, Youn YC, An SS, Kim S (2014) The genetics of Alzheimer’s disease. Clin Interv Aging 9:535–551CrossRefPubMedPubMedCentralGoogle Scholar
  2. 2.
    Hebert LE, Scherr PA, Bienias JL, Bennett DA, Evans DA (2003) Alzheimer disease in the US population: prevalence estimates using the 2000 census. Arch Neurol 60(8):1119–1122CrossRefPubMedGoogle Scholar
  3. 3.
    Scarabino D, Gambina G, Broggio E, Pelliccia F, Corbo RM (2015) Influence of family history of dementia in the development and progression of late-onset Alzheimer’s disease. Am J Med Genet B Neuropsychiatr Genet. doi: 10.1002/ajmg.b.32399
  4. 4.
    Francis PT, Palmer AM, Snape M, Wilcock GK (1999) The cholinergic hypothesis of Alzheimer’s disease: a review of progress. J Neurol Neurosurg Psychiatry 66(2):137–147CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    Mudher A, Lovestone S (2002) Alzheimer’s disease—do tauists and baptists finally shake hands? Trends Neurosci 25(1):22–26CrossRefPubMedGoogle Scholar
  6. 6.
    Goedert M, Spillantini MG, Crowther RA (1991) Tau proteins and neurofibrillary degeneration. Brain Pathol 1(4):279–286CrossRefPubMedGoogle Scholar
  7. 7.
    Iqbal K, Alonso Adel C, Chen S, Chohan MO, El-Akkad E, Gong CX, Khatoon S, Li B, Liu F, Rahman A, Tanimukai H, Grundke-Iqbal I (2005) Tau pathology in Alzheimer disease and other tauopathies. Biochim Biophys Acta 1739(2–3):198–210CrossRefPubMedGoogle Scholar
  8. 8.
    Chun W, Johnson GV (2007) The role of tau phosphorylation and cleavage in neuronal cell death. Front Biosci 12:733–756CrossRefPubMedGoogle Scholar
  9. 9.
    Reiman EM, Webster JA, Myers AJ, Hardy J, Dunckley T, Zismann VL, Joshipura KD, Pearson JV, Hu-Lince D, Huentelman MJ, Craig DW, Coon KD, Liang WS, Herbert RH, Beach T, Rohrer KC, Zhao AS, Leung D, Bryden L, Marlowe L, Kaleem M, Mastroeni D, Grover A, Heward CB, Ravid R, Rogers J, Hutton ML, Melquist S, Petersen RC, Alexander GE, Caselli RJ, Kukull W, Papassotiropoulos A, Stephan DA (2007) GAB2 alleles modify Alzheimer’s risk in APOE epsilon4 carriers. Neuron 54(5):713–720CrossRefPubMedPubMedCentralGoogle Scholar
  10. 10.
    Hardy J, Allsop D (1991) Amyloid deposition as the central event in the aetiology of Alzheimer’s disease. Trends Pharmacol Sci 12(10):383–388CrossRefPubMedGoogle Scholar
  11. 11.
    Zhao Z, Sagare AP, Ma Q, Halliday MR, Kong P, Kisler K, Winkler EA, Ramanathan A, Kanekiyo T, Bu G, Owens NC, Rege SV, Si G, Ahuja A, Zhu D, Miller CA, Schneider JA, Maeda M, Maeda T, Sugawara T, Ichida JK, Zlokovic BV (2015) Central role for PICALM in amyloid-beta blood-brain barrier transcytosis and clearance. Nat Neurosci 18(7):978–987CrossRefPubMedPubMedCentralGoogle Scholar
  12. 12.
    Xiao Q, Gil SC, Yan P, Wang Y, Han S, Gonzales E, Perez R, Cirrito JR, Lee JM (2012) Role of phosphatidylinositol clathrin assembly lymphoid-myeloid leukemia (PICALM) in intracellular amyloid precursor protein (APP) processing and amyloid plaque pathogenesis. J Biol Chem 287(25):21279–21289CrossRefPubMedPubMedCentralGoogle Scholar
  13. 13.
    Rogaeva E, Meng Y, Lee JH, Gu Y, Kawarai T, Zou F, Katayama T, Baldwin CT, Cheng R, Hasegawa H, Chen F, Shibata N, Lunetta KL, Pardossi-Piquard R, Bohm C, Wakutani Y, Cupples LA, Cuenco KT, Green RC, Pinessi L, Rainero I, Sorbi S, Bruni A, Duara R, Friedland RP, Inzelberg R, Hampe W, Bujo H, Song YQ, Andersen OM, Willnow TE, Graff-Radford N, Petersen RC, Dickson D, Der SD, Fraser PE, Schmitt-Ulms G, Younkin S, Mayeux R, Farrer LA, St George-Hyslop P (2007) The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. Nat Genet 39(2):168–177CrossRefPubMedPubMedCentralGoogle Scholar
  14. 14.
    Meng Y, Lee JH, Cheng R, St George-Hyslop P, Mayeux R, Farrer LA (2007) Association between SORL1 and Alzheimer’s disease in a genome-wide study. Neuroreport 18(17):1761–1764CrossRefPubMedPubMedCentralGoogle Scholar
  15. 15.
    Bowden J, Tierney JF, Copas AJ, Burdett S (2011) Quantifying, displaying and accounting for heterogeneity in the meta-analysis of RCTs using standard and generalised Q statistics. BMC Med Res Methodol 11:41CrossRefPubMedPubMedCentralGoogle Scholar
  16. 16.
    Peters JL, Sutton AJ, Jones DR, Abrams KR, Rushton L (2006) Comparison of two methods to detect publication bias in meta-analysis. JAMA 295(6):676–680CrossRefPubMedGoogle Scholar
  17. 17.
    Zhang F, Liu X, Wang B, Cheng Z, Zhao X, Zhu J, Wang D, Wang Y, Dong A, Li P, Jin C (2015) An exploratory study of the association between SORL1 polymorphisms and sporadic Alzheimer’s disease in the Han Chinese population. Neuropsychiatr Dis Treat 11:1443–1448PubMedPubMedCentralGoogle Scholar
  18. 18.
    Wang HZ, Bi R, Hu QX, Xiang Q, Zhang C, Zhang DF, Zhang W, Ma X, Guo W, Deng W, Zhao L, Ni P, Li M, Fang Y, Li T, Yao YG (2014) Validating GWAS-identified risk loci for Alzheimer’s disease in Han Chinese populations. Mol Neurobiol. doi: 10.1007/s12035-014-9015-z
  19. 19.
    Feng X, Hou D, Deng Y, Li W, Tian M, Yu Z (2015) SORL1 gene polymorphism association with late-onset Alzheimer’s disease. Neurosci Lett 584:382–389CrossRefPubMedGoogle Scholar
  20. 20.
    Wen Y, Miyashita A, Kitamura N, Tsukie T, Saito Y, Hatsuta H, Murayama S, Kakita A, Takahashi H, Akatsu H, Yamamoto T, Kosaka K, Yamaguchi H, Akazawa K, Ihara Y, Kuwano R (2013) SORL1 is genetically associated with neuropathologically characterized late-onset Alzheimer’s disease. J Alzheimers Dis 35(2):387–394PubMedGoogle Scholar
  21. 21.
    Ohara T, Ninomiya T, Hirakawa Y, Ashikawa K, Monji A, Kiyohara Y, Kanba S, Kubo M (2012) Association study of susceptibility genes for late-onset Alzheimer’s disease in the Japanese population. Psychiatr Genet 22(6):290–293CrossRefPubMedGoogle Scholar
  22. 22.
    Chen LH, Kao PY, Fan YH, Ho DT, Chan CS, Yik PY, Ha JC, Chu LW, Song YQ (2012) Polymorphisms of CR1, CLU and PICALM confer susceptibility of Alzheimer’s disease in a southern Chinese population. Neurobiol Aging 33(1):210 e211–217CrossRefGoogle Scholar
  23. 23.
    Piaceri I, Bagnoli S, Lucenteforte E, Mancuso M, Tedde A, Siciliano G, Piacentini S, Bracco L, Sorbi S, Nacmias B (2011) Implication of a genetic variant at PICALM in Alzheimer’s disease patients and centenarians. J Alzheimers Dis 24(3):409–413PubMedGoogle Scholar
  24. 24.
    Wang G, Pan XL, Cui PJ, Wang Y, Ma JF, Ren RJ, Deng YL, Xu W, Tang HD, Chen SD (2011) Association study of the GAB2 gene with the risk of Alzheimer disease in the Chinese population. Alzheimer Dis Assoc Disord 25(3):283–285Google Scholar
  25. 25.
    Lambert JC, Zelenika D, Hiltunen M, Chouraki V, Combarros O, Bullido MJ, Tognoni G, Fievet N, Boland A, Arosio B, Coto E, Del Zompo M, Mateo I, Frank-Garcia A, Helisalmi S, Porcellini E, Pilotto A, Forti P, Ferri R, Delepine M, Scarpini E, Siciliano G, Solfrizzi V, Sorbi S, Spalletta G, Ravaglia G, Valdivieso F, Alvarez V, Bosco P, Mancuso M, Panza F, Nacmias B, Bossu P, Piccardi P, Annoni G, Seripa D, Galimberti D, Licastro F, Lathrop M, Soininen H, Amouyel P (2011) Evidence of the association of BIN1 and PICALM with the AD risk in contrasting European populations. Neurobiol Aging 32(4):756 e711–755CrossRefGoogle Scholar
  26. 26.
    Yu JT, Song JH, Ma T, Zhang W, Yu NN, Xuan SY, Tan L (2011) Genetic association of PICALM polymorphisms with Alzheimer’s disease in Han Chinese. J Neurol Sci 300(1–2):78–80CrossRefPubMedGoogle Scholar
  27. 27.
    Ning M, Yang Y, Zhang Z, Chen Z, Zhao T, Zhang D, Zhou D, Xu J, Liu Z, Wang Y, Liu Y, Zhao X, Li W, Li S, He L (2010) Amyloid-beta-related genes SORL1 and ACE are genetically associated with risk for late-onset Alzheimer disease in the Chinese population. Alzheimer Dis Assoc Disord 24(4):390–396CrossRefPubMedGoogle Scholar
  28. 28.
    Kamboh MI, Minster RL, Demirci FY, Ganguli M, Dekosky ST, Lopez OL, Barmada MM (2012) Association of CLU and PICALM variants with Alzheimer’s disease. Neurobiol Aging 33(3):518–521CrossRefPubMedGoogle Scholar
  29. 29.
    Corneveaux JJ, Myers AJ, Allen AN, Pruzin JJ, Ramirez M, Engel A, Nalls MA, Chen K, Lee W, Chewning K, Villa SE, Meechoovet HB, Gerber JD, Frost D, Benson HL, O’Reilly S, Chibnik LB, Shulman JM, Singleton AB, Craig DW, Van Keuren-Jensen KR, Dunckley T, Bennett DA, De Jager PL, Heward C, Hardy J, Reiman EM, Huentelman MJ (2010) Association of CR1, CLU and PICALM with Alzheimer’s disease in a cohort of clinically characterized and neuropathologically verified individuals. Hum Mol Genet 19(16):3295–3301CrossRefPubMedPubMedCentralGoogle Scholar
  30. 30.
    Zhou S, Wang J, Huriletemuer, Wang B, Zhao S, de Wang S, Zhang C, Ma X (2010) Association analysis between polymorphism rs2373115 of gene GRB-associated binding protein 2 and Mongolian Alzheimer patients. Neurosci Lett 480(1):4–6CrossRefPubMedGoogle Scholar
  31. 31.
    Lin K, Tang M, Han H, Guo Y, Lin Y, Ma C (2010) GAB2 is not associated with late-onset Alzheimer’s disease in Chinese Han. Neurol Sci 31(3):277–281CrossRefPubMedGoogle Scholar
  32. 32.
    Cousin E, Mace S, Rocher C, Dib C, Muzard G, Hannequin D, Pradier L, Deleuze JF, Genin E, Brice A, Campion D (2011) No replication of genetic association between candidate polymorphisms and Alzheimer’s disease. Neurobiol Aging 32(8):1443–1451CrossRefPubMedGoogle Scholar
  33. 33.
    Cellini E, Tedde A, Bagnoli S, Pradella S, Piacentini S, Sorbi S, Nacmias B (2009) Implication of sex and SORL1 variants in Italian patients with Alzheimer disease. Arch Neurol 66(10):1260–1266CrossRefPubMedGoogle Scholar
  34. 34.
    Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Williams A, Jones N, Thomas C, Stretton A, Morgan AR, Lovestone S, Powell J, Proitsi P, Lupton MK, Brayne C, Rubinsztein DC, Gill M, Lawlor B, Lynch A, Morgan K, Brown KS, Passmore PA, Craig D, McGuinness B, Todd S, Holmes C, Mann D, Smith AD, Love S, Kehoe PG, Hardy J, Mead S, Fox N, Rossor M, Collinge J, Maier W, Jessen F, Schurmann B, Heun R, van den Bussche H, Heuser I, Kornhuber J, Wiltfang J, Dichgans M, Frolich L, Hampel H, Hull M, Rujescu D, Goate AM, Kauwe JS, Cruchaga C, Nowotny P, Morris JC, Mayo K, Sleegers K, Bettens K, Engelborghs S, De Deyn PP, Van Broeckhoven C, Livingston G, Bass NJ, Gurling H, McQuillin A, Gwilliam R, Deloukas P, Al-Chalabi A, Shaw CE, Tsolaki M, Singleton AB, Guerreiro R, Muhleisen TW, Nothen MM, Moebus S, Jockel KH, Klopp N, Wichmann HE, Carrasquillo MM, Pankratz VS, Younkin SG, Holmans PA, O’Donovan M, Owen MJ, Williams J (2009) Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer’s disease. Nat Genet 41(10):1088–1093CrossRefPubMedPubMedCentralGoogle Scholar
  35. 35.
    Reynolds CA, Hong MG, Eriksson UK, Blennow K, Johansson B, Malmberg B, Berg S, Gatz M, Pedersen NL, Bennet AM, Prince JA (2010) Sequence variation in SORL1 and dementia risk in Swedes. Neurogenetics 11(1):139–142CrossRefPubMedGoogle Scholar
  36. 36.
    Kimura R, Yamamoto M, Morihara T, Akatsu H, Kudo T, Kamino K, Takeda M (2009) SORL1 is genetically associated with Alzheimer disease in a Japanese population. Neurosci Lett 461(2):177–180CrossRefPubMedGoogle Scholar
  37. 37.
    Kolsch H, Jessen F, Wiltfang J, Lewczuk P, Dichgans M, Teipel SJ, Kornhuber J, Frolich L, Heuser I, Peters O, Wiese B, Kaduszkiewicz H, van den Bussche H, Hull M, Kurz A, Ruther E, Henn FA, Maier W (2009) Association of SORL1 gene variants with Alzheimer’s disease. Brain Res 1264:1–6CrossRefPubMedGoogle Scholar
  38. 38.
    Nacmias B, Tedde A, Bagnoli S, Cellini E, Guarnieri BM, Piacentini S, Sorbi S (2009) Implication of GAB2 gene polymorphism in Italian patients with Alzheimer’s disease. J Alzheimers Dis 16(3):513–515CrossRefPubMedGoogle Scholar
  39. 39.
    Feulner TM, Laws SM, Friedrich P, Wagenpfeil S, Wurst SH, Riehle C, Kuhn KA, Krawczak M, Schreiber S, Nikolaus S, Forstl H, Kurz A, Riemenschneider M (2010) Examination of the current top candidate genes for AD in a genome-wide association study. Mol Psychiatry 15(7):756–766CrossRefPubMedGoogle Scholar
  40. 40.
    Sleegers K, Bettens K, Brouwers N, Engelborghs S, van Miegroet H, De Deyn PP, Van Broeckhoven C (2009) Common variation in GRB-associated Binding Protein 2 (GAB2) and increased risk for Alzheimer dementia. Hum Mutat 30(2):E338–344CrossRefPubMedGoogle Scholar
  41. 41.
    Shibata N, Ohnuma T, Baba H, Higashi S, Nishioka K, Arai H (2008) Genetic association between SORL1 polymorphisms and Alzheimer’s disease in a Japanese population. Dement Geriatr Cogn Disord 26(2):161–164CrossRefPubMedGoogle Scholar
  42. 42.
    Minster RL, DeKosky ST, Kamboh MI (2008) No association of SORL1 SNPs with Alzheimer’s disease. Neurosci Lett 440(2):190–192CrossRefPubMedPubMedCentralGoogle Scholar
  43. 43.
    Chapuis J, Hannequin D, Pasquier F, Bentham P, Brice A, Leber I, Frebourg T, Deleuze JF, Cousin E, Thaker U, Amouyel P, Mann D, Lendon C, Campion D, Lambert JC (2008) Association study of the GAB2 gene with the risk of developing Alzheimer’s disease. Neurobiol Dis 30(1):103–106CrossRefPubMedGoogle Scholar
  44. 44.
    Lee JH, Cheng R, Honig LS, Vonsattel JP, Clark L, Mayeux R (2008) Association between genetic variants in SORL1 and autopsy-confirmed Alzheimer disease. Neurology 70(11):887–889CrossRefPubMedGoogle Scholar
  45. 45.
    Li Y, Rowland C, Catanese J, Morris J, Lovestone S, O’Donovan MC, Goate A, Owen M, Williams J, Grupe A (2008) SORL1 variants and risk of late-onset Alzheimer’s disease. Neurobiol Dis 29(2):293–296CrossRefPubMedGoogle Scholar
  46. 46.
    Lee JH, Cheng R, Schupf N, Manly J, Lantigua R, Stern Y, Rogaeva E, Wakutani Y, Farrer L, St George-Hyslop P, Mayeux R (2007) The association between genetic variants in SORL1 and Alzheimer disease in an urban, multiethnic, community-based cohort. Arch Neurol 64(4):501–506CrossRefPubMedPubMedCentralGoogle Scholar
  47. 47.
    Klimkowicz-Mrowiec A, Sado M, Dziubek A, Dziedzic T, Pera J, Szczudlik A, Słowik A (2013). Lack of association of CR1, PICALM and CLU gene polymorphisms with Alzheimer disease in a Polish population. Neurol Neurochir Pol 47(2):157–160Google Scholar
  48. 48.
    Ramirez-Lorca R, Boada M, Saez ME, Hernandez I, Mauleon A, Rosende-Roca M, Martinez-Lage P, Gutierrez M, Real LM, Lopez-Arrieta J, Gayan J, Antunez C, Gonzalez-Perez A, Tarraga L, Ruiz A (2009) GAB2 gene does not modify the risk of Alzheimer’s disease in Spanish APOE 4 carriers. J Nutr Health Aging 13(3):214–219Google Scholar
  49. 49.
    Olgiati P, Politis A, Albani D, Rodilossi S, Polito L, Ateri E, Zisaki A, Piperi C, Liappas I, Stamouli E, Mailis A, Atti AR, Ferrari B, Morini V, Moretti F, Biella G, Forloni G, Papadimitriou GN, Ronchi DD, Kalofoutis A, Serretti A (2012) Association of SORL1 alleles with late-onset Alzheimer’s disease. Findings from the GIGAS_LOAD study and mega-analysis. Curr Alzheimer Res 9(4):491–499Google Scholar
  50. 50.
    Izzo G, Forlenza OV, Santos B, Bertolucci PH, Ojopi EB, Gattaz WF, Kerr DS (2013) Single-nucleotide polymorphisms of GSK3B, GAB2 and SORL1 in late-onset Alzheimer’s disease: interactions with the APOE genotype. Clinics 68(2):277–280CrossRefPubMedPubMedCentralGoogle Scholar
  51. 51.
    Parikh I, Fardo DW, Estus S (2014) Genetics of PICALM expression and Alzheimer’s disease. PLoS One 9(3), e91242CrossRefPubMedPubMedCentralGoogle Scholar
  52. 52.
    Young JE, Boulanger-Weill J, Williams DA, Woodruff G, Buen F, Revilla AC, Herrera C, Israel MA, Yuan SH, Edland SD, Goldstein LS (2015) Elucidating molecular phenotypes caused by the SORL1 Alzheimer’s disease genetic risk factor using human induced pluripotent stem cells. Cell Stem Cell 16(4):373–385CrossRefPubMedPubMedCentralGoogle Scholar
  53. 53.
    Louwersheimer E, Ramirez A, Cruchaga C, Becker T, Kornhuber J, Peters O, Heilmann S, Wiltfang J, Jessen F, Visser PJ, Scheltens P, Pijnenburg YA, Teunissen CE, Barkhof F, van Swieten JC, Holstege H, Van der Flier WM, Alzheimer’s Disease Neuroimaging I, Dementia Competence N (2015) The influence of genetic variants in SORL1 gene on the manifestation of Alzheimer’s disease. Neurobiol Aging 36(3):1605 e1613–1620CrossRefGoogle Scholar
  54. 54.
    Caglayan S, Bauerfeind A, Schmidt V, Carlo AS, Prabakaran T, Hubner N, Willnow TE (2012) Identification of Alzheimer disease risk genotype that predicts efficiency of SORL1 expression in the brain. Arch Neurol 69(3):373–379CrossRefPubMedGoogle Scholar
  55. 55.
    Alexopoulos P, Guo LH, Kratzer M, Westerteicher C, Kurz A, Perneczky R (2011) Impact of SORL1 single nucleotide polymorphisms on Alzheimer’s disease cerebrospinal fluid markers. Dement Geriatr Cogn Disord 32(3):164–170CrossRefPubMedPubMedCentralGoogle Scholar
  56. 56.
    Ganzer S, Arlt S, Schoder V, Buhmann C, Mandelkow EM, Finckh U, Beisiegel U, Naber D, Muller-Thomsen T (2003) CSF-tau, CSF-Abeta1-42, ApoE-genotype and clinical parameters in the diagnosis of Alzheimer’s disease: combination of CSF-tau and MMSE yields highest sensitivity and specificity. J Neural Transm (Vienna) 110(10):1149–1160CrossRefGoogle Scholar
  57. 57.
    Kolsch H, Jessen F, Wiltfang J, Lewczuk P, Dichgans M, Kornhuber J, Frolich L, Heuser I, Peters O, Schulz JB, Schwab SG, Maier W (2008) Influence of SORL1 gene variants: association with CSF amyloid-beta products in probable Alzheimer’s disease. Neurosci Lett 440(1):68–71CrossRefPubMedGoogle Scholar
  58. 58.
    Elias-Sonnenschein LS, Bertram L, Visser PJ (2012) Relationship between genetic risk factors and markers for Alzheimer’s disease pathology. Biomark Med 6(4):477–495Google Scholar
  59. 59.
    Olgiati P, Politis A, Albani D, Rodilossi S, Polito L, Zisaki A, Piperi C, Liappas I, Stamouli E, Mailis A, Batelli S, Forloni G, Marsano A, Balestri M, Soldatos CR, De Ronchi D, Kalofoutis A, Serretti A (2013) Effects of SORL1 gene on Alzheimer’s disease. Focus on gender, neuropsychiatric symptoms and pro-inflammatory cytokines. Curr Alzheimer Res 10(2):154–164CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Ziran Wang
    • 1
  • Hongyan Lei
    • 1
  • Mei Zheng
    • 1
  • Yuxin Li
    • 1
  • Yansen Cui
    • 1
  • Fang Hao
    • 2
  1. 1.Emergency DepartmentLinyi People’s HospitalLinyiChina
  2. 2.Department of NeurologyLiaocheng People’s HospitalLiaochengChina

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