Molecular Neurobiology

, Volume 53, Issue 9, pp 6407–6412 | Cite as

Loss of Heterozygosity of 9p Is Associated with Poorer Survival in Patients with Gliomas

  • Tingfen Huang
  • Shufa Li
  • Zhen Yang
  • Jicheng Liu
  • Yunwei HanEmail author


The prognostic factors associated with the survival of glioma patients have not been well established. Loss of heterozygosity (LOH) of 9p was known to be a typical molecular signature of gliomas, but it was still unclear whether LOH of 9p was associated with poorer survival in patients with gliomas. We searched PubMed and Embase databases from the earliest records to May 2015 to identify studies that met the inclusion criteria. Either a fixed- or a random-effects model was used to calculate the pooled hazard ratio (HR) according to the between-study heterogeneity. Thirteen eligible studies involving 1465 cases of gliomas were included in the meta-analysis. There was little between-study heterogeneity (I 2 = 15 %), and the fixed-effects model was used to calculate the pooled HR. Meta-analysis of total 13 studies showed that LOH of 9p was significantly associated with poorer prognosis of glioma patients (HR = 1.39, 95%CI 1.17–1.64, P = 0.0002). Meta-analysis of eight studies reporting adjusted estimates showed that LOH of 9p was independently associated with poorer prognosis of glioma patients (HR = 1.40, 95%CI 1.14–1.72, P = 0.001). Subgroup analysis by types of gliomas showed that LOH of 9p was significantly associated with poorer prognosis in patients with glioblastoma (HR = 1.34, 95%CI 1.01–1.78, P = 0.04). There was no obvious risk of publication bias shown in the funnel plot. LOH of 9p is significantly associated with poorer prognosis of glioma patients, which is a useful biomarker in predicting patients’ survival.


Loss of heterozygosity 9p Glioma 


Compliance with Ethical Standards

Conflict of Interest

None declared.


None declared.


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Tingfen Huang
    • 1
  • Shufa Li
    • 2
  • Zhen Yang
    • 3
  • Jicheng Liu
    • 4
  • Yunwei Han
    • 5
    Email author
  1. 1.Emergency DepartmentLinyi People’s HospitalLinyiChina
  2. 2.Department of Endocrinology and MetabolismLinyi People’s HospitalLinyiChina
  3. 3.Department of NeurosurgeryAffiliated Hospital of Qingdao UniversityQingdaoChina
  4. 4.Cancer Hospital of Shanghai CityShanghaiChina
  5. 5.Department of OncologyAffiliated Hospital of Sichuan Medical UniversityLuzhouChina

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