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Molecular Neurobiology

, Volume 53, Issue 8, pp 5436–5445 | Cite as

Hints on the Lateralization of Dopamine Binding to D1 Receptors in Rat Striatum

  • Rafael FrancoEmail author
  • Verònica Casadó-Anguera
  • Ana Muñoz
  • Milos Petrovic
  • Gemma Navarro
  • Estefanía Moreno
  • José Luis Lanciego
  • José Luis Labandeira-García
  • Antoni Cortés
  • Vicent Casadó
Article

Abstract

Dopamine receptors in striatum are important for healthy brain functioning and are the target of levodopa-based therapy in Parkinson’s disease. Lateralization of dopaminergic neurotransmission in striata from different hemispheres occurs in patients, but also in healthy individuals. Our data show that the affinity of dopamine binding to dopamine D1 receptors is significantly higher in left than in right striatum. Analysis of data from radioligand binding to striatal samples from naïve, 6-hydroxydopamine lesioned, levodopa-treated and levodopa-induced dyskinetic rats shows differential receptor structure and gives hints on the causes of right/left lateralization of dopamine binding to striatal D1 receptors. Moreover, binding data showed loss of lateralization in levodopa (L-DOPA)-induced dyskinetic rats.

Keywords

Lateralization Basal ganglia G-protein-coupled receptor dimer Dyskinesia 6-hydroxydopamine Cooperativity index 

Notes

Acknowledgments

This work was supported by grants from Spanish Ministerio de Ciencia y Tecnología (SAF2009-07276, SAF2011-23813, and SAF2012-39875-C02-01) and from Spanish Ministerio de Salud (PI09/01756). MMP is supported by Marie Curie CIG PCIG11-GA-2012-322013.

Conflict of Interest

The authors declare no conflict of interest.

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Rafael Franco
    • 1
    • 2
    Email author
  • Verònica Casadó-Anguera
    • 1
    • 2
  • Ana Muñoz
    • 1
    • 3
  • Milos Petrovic
    • 4
    • 5
  • Gemma Navarro
    • 1
    • 2
  • Estefanía Moreno
    • 1
    • 2
  • José Luis Lanciego
    • 1
    • 6
  • José Luis Labandeira-García
    • 1
    • 3
  • Antoni Cortés
    • 1
    • 2
  • Vicent Casadó
    • 1
    • 2
  1. 1.Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)Instituto de Salud Carlos IIIMadridSpain
  2. 2.Molecular Neurobiology Laboratory, Department of Biochemistry and Molecular Biology, Faculty of BiologyUniversity of BarcelonaBarcelonaSpain
  3. 3.Laboratory of Neuroanatomy and Experimental Neurology, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS)University of Santiago de CompostelaSantiago de CompostelaSpain
  4. 4.School of Pharmacy and Biomedical SciencesUniversity of Central Lancashire, PR1 2HEPrestonUK
  5. 5.Institute of Physiology, Academy of SciencesPragueCzech Republic
  6. 6.Laboratory of Neuroanatomy of Basal Ganglia, Neurosciences Division, Center for Applied Medical Research (CIMA)University of NavarraPamplonaSpain

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