Molecular Neurobiology

, Volume 53, Issue 5, pp 2815–2825 | Cite as

SIRT1 and Neural Cell Fate Determination

  • Yulong Cai
  • Le Xu
  • Haiwei XuEmail author
  • Xiaotang FanEmail author


During the development of the central nervous system (CNS), neurons and glia are derived from multipotent neural stem cells (NSCs) undergoing self-renewal. NSC commitment and differentiation are tightly controlled by intrinsic and external regulatory mechanisms in space- and time-related fashions. SIRT1, a silent information regulator 2 (Sir2) ortholog, is expressed in several areas of the brain and has been reported to be involved in the self-renewal, multipotency, and fate determination of NSCs. Recent studies have highlighted the role of the deacetylase activity of SIRT1 in the determination of the final fate of NSCs. This review summarizes the roles of SIRT1 in the expansion and differentiation of NSCs, specification of neuronal subtypes and glial cells, and reprogramming of functional neurons from embryonic stem cells and fibroblasts. This review also discusses potential signaling pathways through which SIRT1 can exhibit versatile functions in NSCs to regulate the cell fate decisions of neurons and glia.


SIRT1 Neural stem cells Neuron Differentiation Deacetylation 



This study was supported by the National Nature Science Foundation of China (No. (81371197, 31271051), Natural Science Foudation Project of CQ CSTC 2013jjB10028.


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of Developmental Neuropsychology, School of PsychologyThird Military Medical UniversityChongqingChina
  2. 2.Southwest Eye Hospital, Southwest Hospital, Third Military Medical UniversityChongqingChina

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