Molecular Neurobiology

, Volume 53, Issue 3, pp 1824–1842 | Cite as

GM1 Ganglioside: Past Studies and Future Potential

  • Massimo Aureli
  • Laura Mauri
  • Maria Grazia Ciampa
  • Alessandro Prinetti
  • Gino Toffano
  • Cynthia Secchieri
  • Sandro Sonnino
Article

Abstract

Gangliosides (sialic acid-containing glycosphingolipids) are abundant in neurons of all animal species and play important roles in many cell physiological processes, including differentiation, memory control, cell signaling, neuronal protection, neuronal recovery, and apoptosis. Gangliosides also function as anchors or entry points for various toxins, bacteria, viruses, and autoantibodies. GM1, a ganglioside component of mammalian brains, is present mainly in neurons. GM1 is one of the best studied gangliosides, and our understanding of its properties is extensive. Simple and rapid procedures are available for preparation of GM1 as a natural compound on a large scale, or as a derivative containing an isotopic radionuclide or a specific probe. Great research interest in the properties of GM1 arose from the discovery in the early 1970s of its role as receptor for the bacterial toxin responsible for cholera pathogenesis.

Keywords

GM1 GM1 Chemistry and Physico-chemistry GM1 and Cholera toxin Cellular organization of GM1 Neurotrophic and neuroprotective properties of GM1 GM1 and the neurodegenerative diseases GM1 and GBS 

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Massimo Aureli
    • 1
  • Laura Mauri
    • 1
  • Maria Grazia Ciampa
    • 1
  • Alessandro Prinetti
    • 1
  • Gino Toffano
    • 2
  • Cynthia Secchieri
    • 2
  • Sandro Sonnino
    • 1
  1. 1.Department of Medical Biotechnology and Translational MedicineUniversity of MilanSegrateItaly
  2. 2.FIDIA FarmaceuticiAbano TermeItaly

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