CLU rs9331888 Polymorphism Contributes to Alzheimer’s Disease Susceptibility in Caucasian But Not East Asian Populations
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Large-scale genome-wide association studies (GWAS) identified three single nucleotide polymorphisms rs11136000, rs2279590, and rs9331888 in CLU gene to be significantly associated with Alzheimer’s disease (AD) in Caucasian ancestry. Both rs11136000 and rs2279590 variants were successfully replicated in Asian population. However, previous studies reported either a weak association or no association between rs9331888 polymorphism and AD in Asian population. Here, we searched the PubMed, AlzGene, and Google Scholar databases. We selected 12 independent studies that evaluated the association between the rs9331888 polymorphism and AD using a case-control design. Using an additive model, we did not identify significant heterogeneity among these 12 studies. We observed significant association between rs9331888 polymorphism and AD in pooled populations (P = 2.26E − 07, odds ratio (OR) = 1.10, 95 % confidence interval (CI) 1.06–1.14). In subgroup analysis, we did not identify significant heterogeneity in both Asian and Caucasian populations. We identified significant association in Caucasian population (P = 1.67E − 08, OR = 1.13, 95 % CI 1.08–1.18) but not in East Asian population (P = 0.49, OR = 1.02, 95 % CI 0.96–1.10).
KeywordsAlzheimer’s disease Single nucleotide polymorphisms Genome-wide association studies (GWAS)
This work was supported by funding from the National Nature Science Foundation of China (Grant Nos. 81300945, 31200934, 31301938, 81471294, 31171219, 81271213, and 81271214) and Harbin Science and Technology Bureau (2014RFXGJ042).
Conflict of Interest
The authors declare no conflict of interest.
- 3.Reitz C, Jun G, Naj A, Rajbhandary R, Vardarajan BN, Wang LS, Valladares O, Lin CF et al (2013) Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E 4, and the risk of late-onset Alzheimer disease in African Americans. JAMA 309:1483–1492Google Scholar
- 8.Chen LH, Kao PY, Fan YH, Ho DT, Chan CS, Yik PY, Ha JC, Chu LW et al (2012) Polymorphisms of CR1, CLU and PICALM confer susceptibility of Alzheimer’s disease in a southern Chinese population. Neurobiol Aging 33(210):e211–217Google Scholar
- 10.Lu SJ, Li HL, Sun YM, Liu ZJ, Yang P, Wu ZY (2014) Clusterin variants are not associated with southern Chinese patients with Alzheimer’s disease. Neurobiol Aging 35(2656):e2659–2611Google Scholar