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Molecular Neurobiology

, Volume 53, Issue 3, pp 1446–1451 | Cite as

CLU rs9331888 Polymorphism Contributes to Alzheimer’s Disease Susceptibility in Caucasian But Not East Asian Populations

  • Shuyan Zhang
  • Xuling Li
  • Guoda Ma
  • Yongshuai Jiang
  • Mingzhi Liao
  • Rennan Feng
  • Liangcai Zhang
  • Jiafeng Liu
  • Guangyu Wang
  • Bin Zhao
  • Qinghua JiangEmail author
  • Keshen LiEmail author
  • Guiyou LiuEmail author
Article

Abstract

Large-scale genome-wide association studies (GWAS) identified three single nucleotide polymorphisms rs11136000, rs2279590, and rs9331888 in CLU gene to be significantly associated with Alzheimer’s disease (AD) in Caucasian ancestry. Both rs11136000 and rs2279590 variants were successfully replicated in Asian population. However, previous studies reported either a weak association or no association between rs9331888 polymorphism and AD in Asian population. Here, we searched the PubMed, AlzGene, and Google Scholar databases. We selected 12 independent studies that evaluated the association between the rs9331888 polymorphism and AD using a case-control design. Using an additive model, we did not identify significant heterogeneity among these 12 studies. We observed significant association between rs9331888 polymorphism and AD in pooled populations (P = 2.26E − 07, odds ratio (OR) = 1.10, 95 % confidence interval (CI) 1.06–1.14). In subgroup analysis, we did not identify significant heterogeneity in both Asian and Caucasian populations. We identified significant association in Caucasian population (P = 1.67E − 08, OR = 1.13, 95 % CI 1.08–1.18) but not in East Asian population (P = 0.49, OR = 1.02, 95 % CI 0.96–1.10).

Keywords

Alzheimer’s disease Single nucleotide polymorphisms Genome-wide association studies (GWAS) 

Notes

Acknowledgments

This work was supported by funding from the National Nature Science Foundation of China (Grant Nos. 81300945, 31200934, 31301938, 81471294, 31171219, 81271213, and 81271214) and Harbin Science and Technology Bureau (2014RFXGJ042).

Conflict of Interest

The authors declare no conflict of interest.

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Shuyan Zhang
    • 1
  • Xuling Li
    • 1
  • Guoda Ma
    • 2
  • Yongshuai Jiang
    • 3
  • Mingzhi Liao
    • 4
  • Rennan Feng
    • 5
  • Liangcai Zhang
    • 6
  • Jiafeng Liu
    • 7
  • Guangyu Wang
    • 8
  • Bin Zhao
    • 2
  • Qinghua Jiang
    • 9
    Email author
  • Keshen Li
    • 2
    Email author
  • Guiyou Liu
    • 10
    Email author
  1. 1.Department of NeurologyThe Fourth Affiliated Hospital, Harbin Medical UniversityHarbinChina
  2. 2.Institute of NeurologyGuangdong Medical CollegeZhanjiangChina
  3. 3.College of Bioinformatics Science and TechnologyHarbin Medical UniversityHarbinChina
  4. 4.College of Life ScienceNorthwest A&F UniversityYanglingChina
  5. 5.Department of Nutrition and Food Hygiene, School of Public HealthHarbin Medical UniversityHarbinChina
  6. 6.Department of StatisticsRice UniversityHoustonUSA
  7. 7.Department of NeurologyThe First Hospital of HarbinHarbinChina
  8. 8.Department of Gastrointestinal Medical OncologyThe Affiliated Tumor Hospital of Harbin Medical UniversityHarbinChina
  9. 9.School of Life Science and TechnologyHarbin Institute of TechnologyHarbinChina
  10. 10.Genome Analysis Laboratory, Tianjin Institute of Industrial BiotechnologyChinese Academy of SciencesTianjinChina

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