Molecular Neurobiology

, Volume 52, Issue 3, pp 1758–1764 | Cite as

Is Cytoplasmic PTEN a Specific Target for Neuronal Survival?



The differential sensitivity of neurons to phosphatase and tensin homolog’s (PTEN) lipid and protein phosphatase actions pose difficulties in defining the exact neuronal phenotype generated by targeting PTEN in neuronal injury. PTEN’s biology beyond its phosphatase functions are also emerging. Considering spatial dynamics of PTEN a decisive factor for its mode of action we propose selective targeting of its cytoplasmic fraction a better therapeutic approach in neuronal injury.


PTEN Neuron Apoptosis Akt 



AK is supported by a Alberta Innovates-Health Solutions (AI-HS) postdoctoral fellowship. The Zochodne laboratory is supported by operating grants from the Canadian Institutes of Health Research (CIHR), the National Institutes of Health (NIH, Diabetes Complications Consortium), and Canadian Diabetes Association.

Conflict of Interest

The authors declare no competing financial interests.


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Division of Neurology, Department of MedicineFaculty of Medicine and Dentistry, University of AlbertaEdmontonCanada

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