Molecular Neurobiology

, Volume 51, Issue 1, pp 89–104 | Cite as

Defective Autophagy in Parkinson’s Disease: Lessons from Genetics

Article

Abstract

Parkinson’s disease (PD) is the most prevalent neurodegenerative movement disorder. Genetic studies over the past two decades have greatly advanced our understanding of the etiological basis of PD and elucidated pathways leading to neuronal degeneration. Recent studies have suggested that abnormal autophagy, a well conserved homeostatic process for protein and organelle turnover, may contribute to neurodegeneration in PD. Moreover, many of the proteins related to both autosomal dominant and autosomal recessive PD, such as α-synuclein, PINK1, Parkin, LRRK2, DJ-1, GBA, and ATPA13A2, are also involved in the regulation of autophagy. We propose that reduced autophagy enhances the accumulation of α-synuclein, other pathogenic proteins, and dysfunctional mitochondria in PD, leading to oxidative stress and neuronal death.

Keywords

Autophagy Parkinson’s disease α-Synuclein PINK1 Parkin 

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Center of Parkinson’s Disease Beijing Institute for Brain Disorders, Key Laboratory for Neurodegenerative Disease of the Ministry of EducationDepartment of Neurobiology Capital Medical UniversityBeijingChina

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