Molecular Neurobiology

, Volume 50, Issue 3, pp 797–810 | Cite as

Crosstalk Between Insulin and Toll-like Receptor Signaling Pathways in the Central Nervous system

  • Fatemeh Hemmati
  • Rasoul Ghasemi
  • Norlinah Mohamed Ibrahim
  • Leila Dargahi
  • Zahurin Mohamed
  • Azman Ali Raymond
  • Abolhassan AhmadianiEmail author


Neuroinflammation is known as a key player in a variety of neurodegenerative and/or neurological diseases. Brain Toll-like receptors (TLRs) are leading elements in the initiation and progression of neuroinflammation and the development of different neuronal diseases. Furthermore, TLR activation is one of the most important elements in the induction of insulin resistance in different organs such as the central nervous system. Involvement of insulin signaling dysregulation and insulin resistance are also shown to contribute to the pathology of neurological diseases. Considering the important roles of TLRs in neuroinflammation and central insulin resistance and the effects of these processes in the initiation and progression of neurodegenerative and neurological diseases, here we are going to review current knowledge about the potential crosstalk between TLRs and insulin signaling pathways in neuroinflammatory disorders of the central nervous system.


Insulin Toll-like receptors Neuroinflammation 


Conflict of Interest

The authors declare that they have no conflict of interests.


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Fatemeh Hemmati
    • 1
  • Rasoul Ghasemi
    • 2
  • Norlinah Mohamed Ibrahim
    • 1
  • Leila Dargahi
    • 3
    • 4
  • Zahurin Mohamed
    • 5
  • Azman Ali Raymond
    • 1
  • Abolhassan Ahmadiani
    • 3
    • 4
    • 5
    Email author
  1. 1.Department of MedicineUniversiti Kebangsaan Malaysia Medical CentreKuala LumpurMalaysia
  2. 2.Neuroscience Research Center and Department of PhysiologyShiraz University of Medical SciencesShirazIran
  3. 3.NeuroBiology Research CenterShahid Beheshti University of Medical SciencesTehranIran
  4. 4.Neuroscience Research CenterShahid Beheshti University of Medical SciencesTehranIran
  5. 5.Department of Pharmacology, Faculty of MedicineUniversity of MalayaKuala LumpurMalaysia

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