Molecular Neurobiology

, Volume 48, Issue 3, pp 404–411

GSK-3β Polymorphism Discriminates Bipolar Disorder and Schizophrenia: A Systematic Meta-Analysis


DOI: 10.1007/s12035-013-8414-x

Cite this article as:
Tang, H., Shen, N., Jin, H. et al. Mol Neurobiol (2013) 48: 404. doi:10.1007/s12035-013-8414-x


Glycogen synthase kinase 3 (GSK-3) is a well-known conserved and ubiquitous protein kinase and playing a pivotal role in neurodevelopment, neurogenesis, learning/memory, and neuronal cell death. Dysfunction of GSK-3 had been seen in multiple neurodegenerative and psychiatric diseases. Bipolar disorder and schizophrenia are two common psychiatric diseases first occur in adolescence or young adulthood. They share similar risk genes as well as clinical symptoms, which make it is difficult to be discriminated from each other. Here, by using meta-analysis we reported that glycogen synthase kinase 3β promoter inactive mutant rs334558 may contribute to the development of schizophrenia not bipolar disorder. This might be used to distinguish these two diseases.


Schizophrenia Bipolar disorder GSK-3 Meta-analysis 

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of PathophysiologyBasic Medical SchoolWuhanPeople’s Republic of China
  2. 2.State Key Laboratory of Environment Health (Incubation), MOE (Ministry of Education) Key Laboratory of Environment & Health, Ministry of Environmental Protection Key Laboratory of Environment and Health (Wuhan), Department of Epidemiology and Biostatistics, School of Public HealthTongji Medical CollegeWuhanPeople’s Republic of China
  3. 3.Clinical Medical CenterNorthern Jiangsu People’s HospitalYangzhouPeople’s Republic of China
  4. 4.Department of GeneticsBasic Medical SchoolWuhanPeople’s Republic of China
  5. 5.Key Laboratory of Neurological Disease of Education Ministry of China, Sino-Canada Cooperation Platform of Neurological Disorder, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanPeople’s Republic of China

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