Molecular Neurobiology

, Volume 47, Issue 2, pp 833–844

Bergmann Glia Function in Granule Cell Migration During Cerebellum Development

  • Haiwei Xu
  • Yang Yang
  • Xiaotong Tang
  • Meina Zhao
  • Fucheng Liang
  • Pei Xu
  • Baoke Hou
  • Yan Xing
  • Xiaohang Bao
  • Xiaotang Fan
Article

DOI: 10.1007/s12035-013-8405-y

Cite this article as:
Xu, H., Yang, Y., Tang, X. et al. Mol Neurobiol (2013) 47: 833. doi:10.1007/s12035-013-8405-y

Abstract

Granule cell migration influences the laminar structure of the cerebellum and thereby affects cerebellum function. Bergmann glia are derived from radial glial cells and aid in granule cell radial migration by providing a scaffold for migration and by mediating interactions between Bergmann glia and granule cells. In this review, we summarize Bergmann glia characteristics and the mechanisms underlying the effect of Bergmann glia on the radial migration of granule neurons in the cerebellum. Furthermore, we will focus our discussion on the important factors involved in glia-mediated radial migration so that we may elucidate the possible mechanistic pathways used by Bergmann glia to influence granule cell migration during cerebellum development.

Keywords

Bergmann glia Migration Cerebellum Development 

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Haiwei Xu
    • 1
  • Yang Yang
    • 2
  • Xiaotong Tang
    • 2
  • Meina Zhao
    • 2
  • Fucheng Liang
    • 2
  • Pei Xu
    • 2
  • Baoke Hou
    • 1
  • Yan Xing
    • 2
  • Xiaohang Bao
    • 2
  • Xiaotang Fan
    • 2
  1. 1.Southwest Eye Hospital, Southwest HospitalThird Military Medical UniversityChongqingPeople’s Republic of China
  2. 2.Department of Histology and EmbryologyThird Military Medical UniversityChongqingPeople’s Republic of China

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