Meta-analysis of the Association Between DCDC2 Polymorphisms and Risk of Dyslexia
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Developmental dyslexia (DD) is a highly heritable neurological disorder that is prevalent in school-aged children. The dyslexia-associated gene DCDC2 is a member of the DCX family of genes known to play roles in neurogenesis, neuronal migration, and differentiation. However, the associations between DCDC2 genetic variations and dyslexia have yielded inconclusive results. Clarifying the effects of DCDC2 polymorphisms on dyslexia risk will advance not only elucidation of the role of DCDC2 in the brain development but also development of possible therapeutic approach for dyslexia. In this review, we summarized the ongoing association studies concerning DCDC2 polymorphisms and dyslexia risk by using meta-analysis and revealed that DCDC2 rs807701 might contribute significantly to dyslexia risk.
KeywordsDCDC2 Polymorphisms Developmental dyslexia Meta-analysis
Doublecortin domain containing protein 2
Transmission disequilibrium test
Single nucleotide polymorphism
This work is partially supported by the National Natural Science Foundation 81273092 to Ranran Song.
Conflicts of Interest
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