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Molecular Neurobiology

, Volume 47, Issue 1, pp 435–442 | Cite as

Meta-analysis of the Association Between DCDC2 Polymorphisms and Risk of Dyslexia

  • Rong Zhong
  • Beifang Yang
  • Hui Tang
  • Li Zou
  • Ranran Song
  • Ling-Qiang ZhuEmail author
  • Xiaoping MiaoEmail author
Article

Abstract

Developmental dyslexia (DD) is a highly heritable neurological disorder that is prevalent in school-aged children. The dyslexia-associated gene DCDC2 is a member of the DCX family of genes known to play roles in neurogenesis, neuronal migration, and differentiation. However, the associations between DCDC2 genetic variations and dyslexia have yielded inconclusive results. Clarifying the effects of DCDC2 polymorphisms on dyslexia risk will advance not only elucidation of the role of DCDC2 in the brain development but also development of possible therapeutic approach for dyslexia. In this review, we summarized the ongoing association studies concerning DCDC2 polymorphisms and dyslexia risk by using meta-analysis and revealed that DCDC2 rs807701 might contribute significantly to dyslexia risk.

Keywords

DCDC2 Polymorphisms Developmental dyslexia Meta-analysis 

Abbreviations

DD

Developmental dyslexia

DCDC2

Doublecortin domain containing protein 2

TDT

Transmission disequilibrium test

OR

Odds ratio

CI

Confidence interval

SNP

Single nucleotide polymorphism

Notes

Acknowledgments

This work is partially supported by the National Natural Science Foundation 81273092 to Ranran Song.

Conflicts of Interest

None.

Supplementary material

12035_2012_8381_MOESM1_ESM.doc (377 kb)
ESM 1 (DOC 377 kb)

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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  1. 1.Department of Epidemiology and Biostatistics, and the Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina
  2. 2.Department of Pathophysiology, Key Lab of Neurological Diseases of Education Ministry, China-Canada Cooperation Platform of Neurological Disease, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina

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