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Molecular Neurobiology

, Volume 45, Issue 3, pp 586–595 | Cite as

The Path from Skin to Brain: Generation of Functional Neurons from Fibroblasts

  • Aisha Iman Abdullah
  • Andrew Pollock
  • Tao SunEmail author
Article

Abstract

Cell fate reprogramming makes possible the generation of new cell types from healthy adult cells to replace those lost or damaged in disease. Additionally, reprogramming patient cells into specific cell types allows for drug screening and the development of new therapeutic tools. Generation of new neurons is of particular interest because of the potential to treat diseases of the nervous system, such as neurodegenerative disorders and spinal cord injuries, with cell replacement therapy. Recent advances in cell fate reprogramming have led to the development of novel methods for the direct conversion of fibroblasts into neurons and neural stem cells. This review will highlight the advantages of these new methods over neuronal induction from embryonic stem cells and induced pluripotent stem cells, as well as outline the limitations and the potential for future applications.

Keywords

Cell fate reprogramming Neurogenesis Fibroblasts Embryonic stem cells (ESCs) Induced pluripotent stem cells (iPSCs) Induced neurons (iNs) Induced neural stem cells (iNSCs) 

Notes

Acknowledgments

This work was supported by New York State Department of Health, C026878 (A. P.), the Ellison Medical Foundation (T. S.), an award from the Hirschl/Weill-Caulier Trust (T. S.), and an R01-MH083680 grant from the NIH/NIMH (T. S.).

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Aisha Iman Abdullah
    • 1
    • 2
  • Andrew Pollock
    • 1
    • 2
  • Tao Sun
    • 1
    • 2
    Email author
  1. 1.Department of Cell and Developmental BiologyWeill Medical College of Cornell UniversityNew YorkUSA
  2. 2.Weill Cornell Graduate School of Medical SciencesWeill Medical College of Cornell UniversityNew YorkUSA

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