Molecular Neurobiology

, Volume 45, Issue 2, pp 234–246 | Cite as

Collapsin Response Mediator Proteins Regulate Neuronal Development and Plasticity by Switching Their Phosphorylation Status

  • Naoya Yamashita
  • Yoshio GoshimaEmail author


Collapsin response mediator protein (CRMP) was originally identified as a molecule involved in semaphorin3A signaling. CRMPs are now known to consist of five homologous cytosolic proteins, CRMP1–5. All of them are phosphorylated and highly expressed in the developing and adult nervous system. In vitro experiments have clearly demonstrated that CRMPs play important roles in neuronal development and maturation through the regulation of their phosphorylation. Several recent knockout mice studies have revealed in vivo roles of CRMPs in neuronal migration, neuronal network formation, synapse formation, synaptic plasticity, and neuronal diseases. Dynamic spatiotemporal regulation of phosphorylation status of CRMPs is involved in many aspects of neuronal development.


Collapsin response mediator protein Semaphorin Reelin BDNF Phosphorylation 



We thank Dr. Toshio Ohshima and all the members of the Department of Molecular Pharmacology and Neurobiology at Yokohama City University. We also thank Dr. Pappachan Kolattukudy, Dr. Jérôme Honnorat, Dr. Nicole Thomasset, and Dr. Masahiko Taniguchi for providing mutant mice and helpful discussion. This work was supported by CREST of JST (Y.G.), grants-in-aid for Scientific Research in a Priority Area from the Ministry of Education, Science, Sports and Culture (Y.G.), JSPS Research Fellowships for Young Scientists (N.Y.), JSPS 21st century COE program (N.Y. and Y.G), and the Yokohama Medical Foundation (N.Y., Y.G.).


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© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of Molecular Pharmacology and NeurobiologyYokohama City University Graduate School of MedicineYokohamaJapan

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