Molecular Neurobiology

, Volume 44, Issue 3, pp 359–373 | Cite as

Functions of Noncoding RNAs in Neural Development and Neurological Diseases

Article

Abstract

The development of the central nervous system (CNS) relies on precisely orchestrated gene expression regulation. Dysregulation of both genetic and environmental factors can affect proper CNS development and results in neurological diseases. Recent studies have shown that similar to protein coding genes, noncoding RNA molecules have a significant impact on normal CNS development and on causes and progression of human neurological disorders. In this review, we have highlighted discoveries of functions of noncoding RNAs, in particular microRNAs and long noncoding RNAs, in neural development and neurological diseases. Emerging evidence has shown that microRNAs play an essential role in many aspects of neural development, such as proliferation of neural stem cells and progenitors, neuronal differentiation, maturation, and synaptogenesis. Misregulation of microRNAs is associated with some mental disorders and neurodegeneration diseases. In addition, long noncoding RNAs are found to play a role in neural development by regulating the expression of protein coding genes. Therefore, examining noncoding RNA-mediated gene regulations has revealed novel mechanisms of neural development and provided new insights into the etiology of human neurological diseases.

Keywords

Neural development Mental disorders Neurodegeneration diseases Noncoding RNAs MicroRNAs (miRNAs) Long noncoding RNAs (lncRNAs) Neural stem cells 

Notes

Acknowledgments

We thank Dr. Dolores Malaspina, Dr. Rajiv Ratan, and Dr. Quanhong Ma for critical reading of the manuscript and providing thoughtful comments. Owing to space limitations, we apologize for being unable to cite many excellent papers in this field. This work was supported by Ellison Medical Foundation (T. S.), an award from Hirschl/Weill-Caulier Trust (T. S.), and an R01-MH083680 grant from NIH/NIMH (T. S.).

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of Cell and Developmental BiologyWeill Medical College of Cornell UniversityNew YorkUSA

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