Molecular Neurobiology

, Volume 44, Issue 1, pp 7–12 | Cite as

The Role of Notch Signaling in Adult Neurogenesis

  • Itaru ImayoshiEmail author
  • Ryoichiro KageyamaEmail author


Neurogenesis occurs throughout adulthood in the mammalian brain. Newly born neurons are incorporated into the functional networks of both the olfactory bulb and the hippocampal dentate gyrus, and there is growing evidence that adult neurogenesis is important for various brain functions. Continuous neurogenesis is achieved by the coordinated proliferation and differentiation of adult neural stem cells. In this review, we discuss the recent findings concerning the roles of Notch signaling in adult neural stem cells.


Notch signaling Rbpj Hes1 Hes5 Adult neurogenesis Neural stem cells 



This work was supported by the grants-in-aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan. I.I. was supported by JST PRESTO program.


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Institute for Virus ResearchKyoto UniversityKyotoJapan
  2. 2.The Hakubi CenterKyoto UniversityKyotoJapan
  3. 3.Japan Science and Technology AgencyPrecursory Research for Embryonic Science and Technology (PRESTO)KyotoJapan
  4. 4.Japan Science and Technology AgencyCore Research for Evolutional Science and Technology (CREST)KyotoJapan

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