Molecular Neurobiology

, Volume 43, Issue 2, pp 114–123 | Cite as

The Role of PML in the Nervous System

Article

Abstract

The promyeloctic leukemia protein PML is a tumor suppressor that was originally identified due to its involvement in the (15;17) translocation of acute promyelocytic leukemia. While the majority of early research has focused upon the role of PML in the pathogenesis of leukemia, more recent evidence has identified important roles for PML in tissues outside the hemopoietic system, including the central nervous system (CNS). Here, we review recent literature on the role of PML in the CNS, with particular focus on the processes of neurodevelopment and neurodegeneration, and propose new lines of investigation.

Keywords

PML PML nuclear body CNS Neural stem cell Neurodegeneration 

Notes

Acknowledgements

We apologize for any omission of references, which was due to space limitations. Laboratory is supported by the Samantha Dickson Brain Tumour Trust and the Wellcome Trust.

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© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Samantha Dickson Brain Cancer UnitUCL Cancer InstituteLondonUK

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