Molecular Neurobiology

, Volume 35, Issue 3, pp 236–244 | Cite as

New Molecular Insights into Cellular Survival and Stress Responses: Neuroprotective Role of Cellular Prion Protein (PrPC)

Article
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Abstract

Knowledge of the physiological function of cellular prion protein has been acquired from prion diseases such as Creutzfeldt–Jakob disease, as well as PRNP knock out and transgenic mice. Recent progress in neurobiology has further delineated the neuroprotective role played by cellular prion protein. In this paper, we review the role of cellular prion protein in cell survival including its antiapoptotic effect on Bax-mediated cell death and its responses to various environmental stresses including oxidative stress, and ischemia. Finally, we discuss the significance of cellular prion protein in different neurodegenerative diseases and the possible development of future therapies.

Keywords

Prion PrPc Neuroprotection Oxidative stress Cell survival TSE 
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Notes

Acknowledgement

We would like to thank Dr. Harry Wilson and Ms. M. Loney for their critical reading of this manuscript. This work was supported in part by research grants from Chen-Han Foundation for Education, Academia Sinica (94M003), National Science Council (NSC93-2314-B-303-009) and Department of Health (DOH95-DC-1103).

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Copyright information

© Humana Press Inc. 2007

Authors and Affiliations

  • Raymond Yen-Yu Lo
    • 1
  • Woei-Cherng Shyu
    • 1
  • Shinn-Zong Lin
    • 1
  • Hsiao-Jung Wang
    • 1
  • Shun-Sheng Chen
    • 2
  • Hung Li
    • 3
    • 4
  1. 1.Department of Neurology, Neuro-Medical Scientific Center, Buddhist Tzu-Chi General HospitalTzu-Chi UniversityHualienTaiwan
  2. 2.Department of Neurology, Chang Gung Memorial Hospital, Kaohsiung Medical CenterChang Gung University College of MedicineKaohsiungTaiwan
  3. 3.Institute of Molecular BiologyTaipeiTaiwan
  4. 4.Institute of BiochemistryNational Yang-Ming UniversityTaipeiTaiwan

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