Molecular Neurobiology

, Volume 36, Issue 1, pp 102–112

The Cannabinoid CB1 Receptor Antagonist, Rimonabant, as a Promising Pharmacotherapy for Alcohol Dependence: Preclinical Evidence

  • Giancarlo Colombo
  • Alessandro Orrù
  • Paola Lai
  • Claudia Cabras
  • Paola Maccioni
  • Marina Rubio
  • Gian Luigi Gessa
  • Mauro A. M. Carai


Several lines of preclinical evidence indicate the ability of the prototypic cannabinoid CB1 receptor antagonist, rimonabant, to suppress various alcohol-related behaviors, including alcohol drinking and seeking behavior and alcohol self-administration in rats and mice. Together, these data—synthetically reviewed in the present paper—suggest (a) the involvement of the cannabinoid CB1 receptor in the neural substrate controlling alcohol intake, alcohol reinforcement, and the motivational properties of alcohol and (b) that rimonabant may constitute a new and potentially effective medication for the treatment of alcohol dependence.


Cannabinoid CB1 receptor antagonist, rimonabant Alcohol Alcohol dependence (alcoholism) Alcohol drinking and seeking behavior Animal models of alcoholism 


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Copyright information

© Humana Press Inc. 2007

Authors and Affiliations

  • Giancarlo Colombo
    • 1
  • Alessandro Orrù
    • 2
  • Paola Lai
    • 1
  • Claudia Cabras
    • 2
  • Paola Maccioni
    • 1
  • Marina Rubio
    • 3
  • Gian Luigi Gessa
    • 1
  • Mauro A. M. Carai
    • 1
  1. 1.C.N.R. Institute of NeuroscienceCagliari (CA)Italy
  2. 2.Department of NeuroscienceUniversity of CagliariCagliariItaly
  3. 3.Department of Biochemistry and Molecular BiologyComplutense UniversityMadridSpain

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