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Injectable nanocurcumin-dispersed gelatin–pluronic nanocomposite hydrogel platform for burn wound treatment

  • Le Hang Dang
  • Ngoc Trinh Huynh
  • Ngoc Oanh Pham
  • Cong Truc Nguyen
  • Minh Thanh Vu
  • Van Thoai Dinh
  • Van Thu Le
  • Ngoc Quyen TranEmail author
Article
  • 38 Downloads

Abstract

To utilize the potent pharmaceutical properties of curcumin (Cur) and gelatin-based materials in tissue regeneration, we fabricated a thermosensitive nanocomposite hydrogel based on pluronic-grafted gelatin (PG) and nanocurcumin (nCur) to enhance burn healing. In this method, the amphiphilic PG played a role as a surfactant to prepare and protect nanosized Cur particles, which could overcome the poor dissolution of the phytochemical. The synthesized PG was identified by \(^{1}\hbox {H}\) nuclear magnetic resonance. Depending on the amount of Cur, size distribution of the dispersed nCur ranged from 1.5 ± 0.5 to 16 ± 3.2 nm as observed using transmission electron microscopy and dynamic light scattering. The nCur-dispersed PG solution formed nCur–PG nanocomposite hydrogel on warming up to \(35{^{\circ }}\hbox {C}\). Release profile indicated sustainable release of Cur from the injectable platform. Fibroblast cells were well proliferated on the nanocomposite hydrogel. The nCur–PG enhanced the healing process of second-degree burn wound. These results showed potential applications of the biomaterial in tissue regeneration.

Keywords

Nanocurcumin gelatin pluronic F127 nanocomposite hydrogel wound healing 

Notes

Acknowledgements

This work was financially supported by Tra Vinh University under grant number 1434/HD.DHTV-KHCN and Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number 104.02-2017.60.

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Copyright information

© Indian Academy of Sciences 2019

Authors and Affiliations

  • Le Hang Dang
    • 1
    • 2
  • Ngoc Trinh Huynh
    • 3
    • 4
  • Ngoc Oanh Pham
    • 1
    • 3
  • Cong Truc Nguyen
    • 3
  • Minh Thanh Vu
    • 5
  • Van Thoai Dinh
    • 2
    • 6
  • Van Thu Le
    • 2
    • 3
  • Ngoc Quyen Tran
    • 2
    • 3
    • 6
    Email author
  1. 1.School of Biotechnology, International UniversityNational Universities in HCMCHo Chi Minh CityViet Nam
  2. 2.Graduate University of Science and TechnologyHo Chi Minh CityViet Nam
  3. 3.Institute of Applied Materials ScienceViet Nam Academy of Science and TechnologyHo Chi Minh CityViet Nam
  4. 4.Faculty of ChemistryTra Vinh UniversityTra Vinh ProvinceViet Nam
  5. 5.Institute of Chemistry and MaterialsCau Giay, Ha NoiViet Nam
  6. 6.NTT Hi-Tech InstituteNguyen Tat Thanh UniversityHo Chi Minh CityViet Nam

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