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Nanogels of acetylated ulvan enhance the solubility of hydrophobic drug curcumin

  • Truong Hai Bang
  • Tran Thi Thanh Van
  • Le Xuan Hung
  • Bui Minh LY
  • Nguyen Duy Nhut
  • Thanh Thuy Thu Thuy
  • Bui The Huy
Article
  • 17 Downloads

Abstract

Curcumin (Cur) is a polyphenol showing various bioactivities including anti-tumour activity. However, poor solubility of Cur in aqueous solution is a major barrier to its bioavailability and clinical efficacy. In this study, hydrophobically modified ulvan was considered to self-assemble to fabricate nanogels. This is a network of hydrophilic segments with hydrophobic microdomains in the nanopores, which keeps Cur from dispersing into the media and raise Cur solubility in water by 20,000 times. A Cur-loaded acetylated ulvan nanogel was characterized by scanning electron microscopy, transmission electron microscopy and dynamic light scattering. This result confirmed that hydrophobically modified ulvan could be used as a self-organizing assembly nanogel to carry and deliver water-insoluble bioactive compounds.

Keywords

Nanogel ulvan curcumin green seaweed 

Notes

Acknowledgements

This research is funded by the Vietnam Academy of Science and Technology (Project number VAST03.04/15-16).

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Copyright information

© Indian Academy of Sciences 2019

Authors and Affiliations

  • Truong Hai Bang
    • 1
  • Tran Thi Thanh Van
    • 1
  • Le Xuan Hung
    • 2
  • Bui Minh LY
    • 1
  • Nguyen Duy Nhut
    • 1
  • Thanh Thuy Thu Thuy
    • 3
  • Bui The Huy
    • 2
    • 4
  1. 1.Nhatrang Institute of Technology Research and ApplicationVietnam Academy of Science and TechnologyNha TrangVietnam
  2. 2.Institute of Research and DevelopmentDuy Tan UniversityDa NangVietnam
  3. 3.Institute of ChemistryVietnam Academy of Science and TechnologyCau Giay HanoiVietnam
  4. 4.Department of ChemistryChangwon NationalChangwonRepublic of Korea

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