Bulletin of Materials Science

, 41:142 | Cite as

Composite of AuNPs@SiO\(_{2}\)NPs@[(NIPAM)-\({\varvec{b}}\)-(Ala)] and its activity on leukemia cells

  • Chander AmgothEmail author
  • Mohan Lakavathu
  • D S D Suman Joshi


Synthesis and characterization of thermo-sensitive block copolymer of N-isopropyl acryl amide-b-Alanine [(NIPAM)-b-(Alanine)] thin film and its doping with (AuNPs)–(\(\hbox {SiO}_{2}\hbox {NPs}\)), (gold and silica nanoparticles) were reported. Further, composite effect on K562 (leukemia) cells was examined based on in vitro cell-based studies. The synthesis of \(\hbox {SiO}_{2} \hbox {NPs}\) was followed through facile Stober’s sol–gel synthesis methods. The individual morphology of [(NIPAM)-b-(Alanine)] thin film, AuNPs and \(\hbox {SiO}_{2 }\)NPs including [(NIPAM)-b-(Alanine)]@(Au)-(\(\hbox {SiO}_{2} \hbox {NPs}\)) composite was confirmed by using TEM instrumentation. [(NIPAM)-b-(Alanine)] thin film was embedded with gold and silica nanoparticles followed by the sonication. The average size of AuNPs is 16 nm and for \(\hbox {SiO}_{2}\hbox {NPs}\), it is \({\sim }\)368 nm (in diameter). Synthesized composite [(NIPAM)-b-(Alanine)]@(Au)@(\(\hbox {SiO}_{2}\hbox {NPs}\)) is biocompatible for mankind use. However, composite used to examine the inhibitory activity on K562 cells and it shows \(\sim \)78% inhibition, which is significant value for 24 h treatment under humidified atmospheric conditions.


Composite gold nanoparticles silica nanoparticles cell inhibition [(NIPAM)-b-(Alanine)] 



We would like to acknowledge University Grants Commission for financial assistance under the Rajiv Gandhi National Fellowship Scheme.

Supplementary material

12034_2018_1657_MOESM1_ESM.docx (3.6 mb)
Supplementary material 1 (docx 3643 KB)


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Copyright information

© Indian Academy of Sciences 2018

Authors and Affiliations

  • Chander Amgoth
    • 1
    Email author
  • Mohan Lakavathu
    • 2
  • D S D Suman Joshi
    • 3
  1. 1.School of Engineering Sciences and TechnologyUniversity of HyderabadHyderabadIndia
  2. 2.School of ChemistryUniversity of HyderabadHyderabadIndia
  3. 3.Department of BiotechnologyAcharya Nagarjuna UniversityGunturIndia

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