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Thioglycolic acid-capped CdS quantum dots modified with \(\hbox {Co}^{2+}\) as a fluorescent sensor for dopamine

  • Tuanjai Noipa
  • Wittaya Ngeontae
Article
  • 57 Downloads

Abstract

A new selective fluorescent sensor for detection of dopamine (DA) using \(\hbox {Co}^{2+}\) -decorated thioglycolic acid-capped CdS QDs (\(\hbox {Co}^{2+}\)@TGA–CdS QDs) was proposed. Basically, the fluorescent intensity of TGA–CdS QDs can be quenched by \(\hbox {Co}^{2+}\). However, with the addition of dopamine into the solution of \(\hbox {Co}^{2+}\)@TGA–CdS QDs, the fluorescent intensity was efficiently quenched due to the formation of the efficient quencher (\(\hbox {Co}^{2+}\)–dopamine complex). Thus, the concentration of dopamine can be determined by tracking the decrease in the fluorescent intensity of the \(\hbox {Co}^{2+}\)@TGA–CdS QDs. The proposed sensor showed high selectivity towards the detection of dopamine over other catecholamine derivatives and related compounds. Under optimal conditions, the quenching efficiency of dopamine on the \(\hbox {Co}^{2+}\)@TGA–CdS QDs system was linearly proportional to the concentration of dopamine in the range of \(20{-}100\,{\upmu }\hbox {mol }\hbox {l}^{-1}\). The limits of detection and quantification were 1.8 and \(12.7\,{\upmu }\hbox {mol }\hbox {l}^{-1}\), respectively. This sensor system was demonstrated to detect dopamine in real urine samples with satisfactory results.

Keywords

Fluorescent sensors quantum dots fluorescent quenching dopamine 

Notes

Acknowledgements

This research was financially supported by the Thailand Research Fund (RSA6080006) and the Center of Excellence for Innovation in Chemistry (PERCH-CIC), Office of the Higher Education Commission, Ministry of Education.

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Copyright information

© Indian Academy of Sciences 2018

Authors and Affiliations

  1. 1.Materials Chemistry Research Center, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of ScienceKhon Kaen UniversityKhon KaenThailand
  2. 2.Faculty of Science and EngineeringKasetsart UniversitySakon NakhonThailand
  3. 3.Research Center for Environmental and Hazardous Substance ManagementKhon Kaen UniversityKhon KaenThailand
  4. 4.Center of Excellence for Environmental and Hazardous Waste Management (EHWM)BangkokThailand

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