Synthesis and characterization of SPIO-loaded PEG-b-PS micelles as contrast agent for long-term nanoparticle-based MRI phantom

  • Man Theerasilp
  • Witaya Sungkarat
  • Norased Nasongkla
Article
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Abstract

Nanoparticle-based magnetic resonance imaging (MRI) phantom was developed from the suspension of magnetic nanoparticles composing methoxy poly(ethylene glycol)-block-poly(styrene) (PEG-b-PS) micelles and superparamagnetic iron oxide (SPIO) nanoparticles in the core of micelles. The size of SPIO-loaded micelles was determined by dynamic light scattering (DLS) and transmission electron microscopy. Larger-size micelles were found when SPIO loading was increased. The effect of the hydrophobic section of block copolymer on the size of micelles was studied by DLS. Transverse relaxivity was evaluated on both 1.5 and 3 T clinical MRI scanner. Higher SPIO-loading provided higher relaxivity, where the relaxivity of 10% SPIO-loaded PEG(5 kDa)-b-PS(5 kDa) were 144.0 and \(174.0~\hbox {m M}^{-1}~\hbox {s}^{-1}\) for 1.5 and 3 T MRI, respectively. This formulation showed stability over a 10-week period, and the standard deviations of the relaxivities were 3.0 and 8.0% for 1.5 and 3 T MRI, respectively. Thus, SPIO-loaded PEG-b-PS micelles have a potential to be applied as a contrast agent for nanoparticle-based MRI phantom.

Keywords

Iron oxide nanoparticle polymeric micelles stability relaxivity MRI phantom 

Notes

Acknowledgements

This research was supported by Mahidol University, Thailand.

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Copyright information

© Indian Academy of Sciences 2018

Authors and Affiliations

  • Man Theerasilp
    • 1
    • 2
  • Witaya Sungkarat
    • 3
  • Norased Nasongkla
    • 1
    • 2
  1. 1.Department of Biomedical Engineering, Faculty of EngineeringMahidol UniversityPhutthamonthonThailand
  2. 2.Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of ScienceMahidol UniversityBangkokThailand
  3. 3.Department of Radiology, Faculty of Medicine, Ramathibodi HospitalMahidol UniversityBangkokThailand

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