Bulletin of Materials Science

, Volume 36, Issue 1, pp 171–174 | Cite as

Development of hydroxyapatite bone cement for controlled drug release via tetracycline hydrochloride

Article

Abstract

The purpose of this work was to study the preparation and characterization of drug–hydroxyapatite cement. The hydroxyapatite (HA) cement has been synthesized by using tricalcium phosphate, calcium carbonate and dicalcium phosphate anhydrous with sodium hydrogen phosphate as liquid phase. The effect of added tetracycline hydrochloride (TCH) as drug on final phases, microstructure, setting behaviour and compressive strength has been studied. The drug release rate was first order within the first day and then was zero order. No obvious difference could be detected in XRD patterns of the TCH–HA cement with various amounts of drug. By increasing the drug concentration, mechanical strength of cement was decreased and its setting time was increased. The results of this study demonstrate the potential of using HA cement as a carrier for drug delivery.

Keywords

Calcium phosphate bone cement tetracycline hydrochloride drug delivery 

References

  1. Barralet J E, Grover L M and Gbureck U 2004 J. Biomater. 25 2197CrossRefGoogle Scholar
  2. Fernández E, Sarda S and Hamcerencu M 2005 J. Biomater. 26 2289CrossRefGoogle Scholar
  3. Ginebra M P, Traykova T and Planell J A 2006 J. Control. Release 113 102CrossRefGoogle Scholar
  4. Hench L 1991 J. Am. Ceram. Soc. 74 1487CrossRefGoogle Scholar
  5. Ishikawa K, Miyamoto Y, Kon M, Nagayama M and Asaoka K 1995 J. Biomater. 16 527CrossRefGoogle Scholar
  6. Josse S et al 2005 J. Biomater. 26 2073CrossRefGoogle Scholar
  7. Knabe C, Driessens F C M, Planell J A and Gildenhar R 2000 J. Biomed. Mater. Res. 52 498CrossRefGoogle Scholar
  8. Komath M, Varma H K and Ivakumar R 2000 Bull. Mater. Sci. 23 135CrossRefGoogle Scholar
  9. Lebugle A, Rodrigues A, Bonnevialle P, Voigt J J, Canal P and Rodriguez F 2002 J. Biomater. 23 3517CrossRefGoogle Scholar
  10. Okada Y, Kawanabe K, Fujita H, Nishio K and Nakamura T 1999 J. Biomed. Mater. Res. 47 353CrossRefGoogle Scholar
  11. Ooms E M, Wolke J G C and de Heuvel M T U 2003 J. Biomater. 24 989CrossRefGoogle Scholar
  12. Peter B et al 2005 Bone 36 52CrossRefGoogle Scholar
  13. Rabiee S M, Moztarzadeh F, Solati-Hashjin M and Salimi-Kenari H 2008 Am. Ceram. Soc. Bull. 87 43Google Scholar
  14. Schnieders J, Gbureck U, Thull R and Kissel T 2006 J. Biomater. 27 4239CrossRefGoogle Scholar
  15. Sokolova V, Radtke I F, Heumann R and Epple M 2006 J. Biomater. 27 3147CrossRefGoogle Scholar
  16. Suchaneck W and Yoshimura M 1998 J. Mater. Res. 13 95Google Scholar
  17. Takagi S, Chow L C and Ishikawa K 1998 J. Biomater. 19 1593CrossRefGoogle Scholar
  18. Ueno Y, Futagawa H, Takagi Y, Ueno A and Mizushima Y 2005 J. Control. Release 103 93CrossRefGoogle Scholar
  19. Yang Q, Troczynki T and Liu D M 2002 J. Biomater. 23 2751CrossRefGoogle Scholar

Copyright information

© Indian Academy of Sciences 2013

Authors and Affiliations

  1. 1.Department of Mechanical EngineeringBabol University of TechnologyBabolIran

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